Forskning ved Københavns Universitet - Københavns Universitet

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Anja Tatiana Ramstedt Jensen

Anja Tatiana Ramstedt Jensen

Professor

  • Parasitology

    Blegdamsvej 3B, 2200 Kbh. N, Bygning: 07-11-38

    Telefon: +45 35 32 76 82

Medlem af:

  • TARGETS team

As head of the TARGETS team my focus is on a family of "sticky" proteins known as the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). P. falciparum is the most pathogenic malaria parasite and a major cause of morbidity and mortality among children in sub-Saharan Africa. The virulence of P. falciparum is linked to its expression of PfEMP1 on the surface of infected erythrocytes; these proteins enable the parasites to "stick" to capillaries of the host and are involved in pathogenesis as well of development of immunity to malaria. We have identified a subset of PfEMP1 proteins of importance in severe malaria and are currently investigating their involvement in the molecular mechanisms elicited in cerebral malaria.

Primære forskningsområder

Research projects include in vitro molecular and immunological characterization of malaria PfEMP1 proteins associated with severe malaria in young children. I always have bachelor and masters projects on hand; please contact (here) if you are interested in learning more about research done in my research group.

For Mendeley stats and citations see here.

My Researcher Profile at Google Scholar is here.

My ResearcherID profile is here.

My ResearchGate profile is here.

Interesseområder

  • Immunology and pathogenesis of severe P. falciparum malaria with a particular focus on cerebral malaria in children
  • Enhancing malaria research capacity in Africa

Undervisnings- og vejledningsområder

Teaching immunology to undergraduate and graduate students at the Faculty of Health and Medical Sciences. University Coordinator of the MSc course “Chronic Inflammation. From Basic Research to Therapy”.

Mulige interessekonflikter

None

Udvalgte publikationer

  1. Udgivet

    Natural and vaccine-induced acquisition of cross-reactive IgG inhibiting ICAM-1-specific binding of a Plasmodium falciparum PfEMP1 subtype associated specifically with cerebral malaria

    Olsen, R. W., Ecklu-Mensah, G., Bengtsson, A., Ofori, M. F., Lusingu, J. P. A., Castberg, F. C., Hviid, L., Adams, Y. & Jensen, A. T. R., 2018, I : Infection and Immunity. 86, 4, 17 s., e00622-17.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  2. Udgivet

    Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

    Lennartz, F., Adams, Y., Bengtsson, A., Olsen, R. W., Turner, L., Ndam, N. T., Ecklu-Mensah, G. D., Moussiliou, A., Ofori, M. F., Gamain, B., Lusingu, J. P., Petersen, J. E. V., Wang, C. W., Nunes-Silva, S., Jespersen, J. S., Lau, C. K. Y., Theander, T. G., Lavstsen, T., Hviid, L., Higgins, M. K. & Jensen, A. T. R., 8 mar. 2017, I : Cell Host & Microbe. 21, 3, s. 403-414 12 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  3. Udgivet

    PfEMP1 – a parasite protein family of key importance in Plasmodium falciparum malaria immunity and pathogenesis

    Hviid, L. & Jensen, A. T. R., apr. 2015, Advances in Parasitology. Rollinson, D. & Stothard, J. R. (red.). Bind 88. s. 51-84 34 s. (Advances in Parasitology).

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

  4. Udgivet

    Mapping the binding site of a cross-reactive Plasmodium falciparum PfEMP1 monoclonal antibody inhibitory of ICAM-1 binding

    Lennartz, F., Bengtsson, A., Olsen, R. W., Joergensen, L., Brown, A., Remy, L., Man, P., Forest, E., Barfod, L. K., Adams, Y., Higgins, M. K. & Jensen, A. T. R., 2015, I : Journal of immunology (Baltimore, Md. : 1950). 195, 7, s. 3273-83 11 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  5. Udgivet

    A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

    Bengtsson, A., Joergensen, L., Rask, T. S., Olsen, R. W., Andersen, M. A., Turner, L., Theander, T. G., Hviid, L., Higgins, M. K., Craig, A., Brown, A. & Jensen, A. T. R., 2013, I : Journal of Immunology. 190, 1, s. 240-9 10 s.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  6. Udgivet

    Surface co-expression of two different PfEMP1 antigens on single Plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1

    Joergensen, L., Bengtsson, D. C., Bengtsson, A., Ronander, E., Berger, S. S., Turner, L., Dalgaard, M. B., Cham, G. K. K., Victor, M. E., Lavstsen, T., Theander, T. G., Arnot, D. E. & Jensen, A. T. R., 2010, I : PLoS Pathogens. 6, 9, s. e1001083

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

ID: 11501