Forskning ved Københavns Universitet - Københavns Universitet

Forside
Dereck Edward Winston Chatterton
Dereck Edward Winston Chatterton

Lektor

Academic Degrees:

2002: Degree of Ph.D. Dept. of Molecular Biology, Protein Chemistry Laboratory, University of Aarhus, Denmark & jointly at Dept. of Nutrition, UC Davis California

1990: Degree of Master of Science (Biostructural Chemistry). University of Aarhus, Denmark.

1985: Degree of Batchelor of Science, University of Dundee, Scotland, Biochemistry

1982: Fellowship of the Institute of Medical Laboratory Sciences, 1982 Bristol Polytechnic, UK

1979: Higher National Diploma in Medical Laboratory Sciences, 1979. Bristol Polytechnic, UK

Academic Employment:

2016: Associate Professor, Bioactivity of Milk Proteins and Peptides (Tenure), ongoing

2015: Associate Professor of Dairy Biochemistry and Technology, FOOD and also Section of Comparative Paediatrics and Nutrition, Faculty of Health and Medical Sciences, University of Copenhagen

2014: Associate Professor of Dairy Biochemistry and Technology, FOOD, Faculty of Science and also Department of Human Nutrition, Exercise and Sports, section of Clinical and Experimental Nutrition, University of Copenhagen

2009: Associate Professor of Dairy Biochemistry and Technology, FOOD, Faculty of Science, University of Copenhagen

2007: Senior Postdoctoral Research Fellow, Dublin Oxford Glycobiology Lab, UC Dublin

2006: Biochemist, Oligosaccharide Research Lab, Moorepark Food Research Centre, Ireland

2002-2006: Visiting researcher, (Post.doc), Dept. of Molecular Biology, Protein Chemistry Laboratory, University of Aarhus, Denmark

1995-2006: Biochemist, Arla Foods Innovation, Denmark

2000: Staff Research Associate, Dept. of Nutrition, University of California Davis

1998: Visiting Researcher, Dept. of Nutrition, University of California Davis

1995: Biochemist, R&D Laboratory MD Foods Ingredients, Denmark

1991: Biochemist, R&D Laboratory Danmark Protein, Denmark

1991: Clinical Research Assistant, Institute of Experimental Clinical Research, University of Aarhus 

Research Leadership:

  • 15 years experience at Arla Foods Ingredients. Head, R&D Laboratory, several technical staff.
  • Formal leadership training courses, Arla Foods.
  • Project leader, Bioactive Milk Components; Alpha-lactalbumin, GMP, Osteopontin preclinical documentation.
  • Co-investigator, since starting at University of Copenhagen in 2009, on several projects including DSF-FØSU grants.
  • Extensive collaboration among local, national and international partners.
  • International experience from 4 research stays abroad at University of California at Davis, Moorepark Food research Centre and University College, Dublin.
  • Deputy research group leader of in Dairy Technology Section at FOOD.
  • Main supervisor and co-supervisor of several students and PhD students.
  • EU Project Coordination: Representative for Arla Foods within the Framework European Programme, MADGELAS, with partners from European universities, institutes and industries.
  • Member of Cost Action “Infogest” Food Digestion Network, 200 participants, 60 institutions in 27 countries
  • Dairy Internship Committee Member, University of Copenhagen
  • Dairy Industry Coordination Group
  • Chairman Innovation Committee June 2009-December 2009
  • Research and Innovation Committee, (Responsible for Innovation) Department of Food Science, University of Copenhagen,
  • Participation in Management Group, Department of Food Science, University of Copenhagen; Member, Industrigruppe for sikring af mejeriingeniøruddannelsens fremtid, FOOD Strategy Committee (from February 2013) Department of Food Science, University of Copenhagen.

Selected Publications:

~30 publications in international journals, including 3 US patents, 3 book chapters

NGUYEN, D.N., JIANG, P., STENSBALLE, A., BENDIXEN, E., SANGILD, P.T. & CHATTERTON, D.E.: (2015) Bovine lactoferrin regulates cell survival, apoptosis and iron-dependent pathways in intestinal epithelial cells and preterm pig intestine. Submitted.

NGUYEN, D.N., SANGILD, P.T., Li, Y., BERING, S.B. & CHATTERTON, D.E. (2015) Processing of whey modulates proliferative and immune functions in intestinal epithelial cells. Submitted.

NGUYEN, D.N., JIANG, P., JACOBSEN, S., SANGILD, P.T., BENDIXEN, E., & CHATTERTON, D.E.: (2015)

Protective effects of transforming growth factor β2 in intestinal cells by regulation of proteins associated with stress and endotoxin responses. PloS One 10(2):e0117608

JENSEN, H.B., PEDERSEN, K.S., JOHANSEN, L.B., POULSEN, N.A., BAKMAN, M, CHATTERTON, D.E. & LARSEN, L.B.: (2015) Genetic variation and posttranslational modification of bovine κ-casein: effects on caseino-macropeptide release during renneting J Dairy Sci 98(2): 747-758

NGUYEN, D.N., SANGILD, P.T., OSTERGAARD, M.V., BERING, S.B. & CHATTERTON, D.E.: (2014) Tranforming growth factor-β2 and endotoxin interact to regulate homeostasis via interleukin-8 levels in the immature intestine. Am J Physiol Gastrointest Liver Physiol 307(7):G689-99

LI, Y., JENSEN, M.L., CHATTERTON, D.E.W., JENSEN, B.B., THYMANN, T., KVISTGAARD, A.S. & SANGILD, P.T.: (2014) Raw bovine milk improves gut responses to feeding relative infant formula in preterm piglets. Am J Physiol Gastrointest Liver Physiol 306(1):G81-G90

NGUYEN, D.N., Li, Y., SANGILD, P.T., BERING, S.B. & CHATTERTON, D.E.W.: (2014) Effects of bovine lactoferrin on the immature porcine intestine Br. J. Nutr 111(2): 321-331

LI, Y., OSTERGAARD, M.V., JIANG, P., CHATTERTON, D.E., THYMANN, T., KVISTGAARD, A.S. & SANGILD, P.T.: (2013) Whey protein processing influences formula-induced gut maturation in preterm pigs. J. Nutr 143(12):1934-1942

CHATTERTON, D.E.W., NGUYEN, D.N., BERING, S.B., SANGILD, P.T.: (2013) Anti-inflammatory mechanisms of bioactive milk proteins in the newborn intestine. Int J Biochem Cell Biol 45(8):1730-1747

STØY, A.C., SANGILD, P., SKOVGAARD, K., THYMANN, T., BJERRE, M., CHATTERTON, D., PURUP, S., BOYE, M., SCHMIDT, M., HEEGAARD, P.: (2013) Mild heat treatment does not reduce the colitis-protective effects of bovine colostrum in preterm pigs. J Pediatr Gastroenterol Nutr 56, Supplement 2, 401

LI, Y., THOMAS, T., KVISTGAARD, A.S., CHATTERTON, D:E:W., & SANGILD, P:T.: (2013) Heat treatment of milk reduces intestinal function and resistance to necrotizing enterocolitis in preterm pigs J Pediatr Gastroenterol Nutr 56, Supplement 2, 440

NGUYEN, D.N., LI, Y., SANGILD, P.T., BERING, S.B. & CHATTERTON, D.E.W.: (2013) Lactoferrin-enriched formula modulates necrotizing enterocolitis and intestinal inflammation in preterm pigs J Pediatr Gastroenterol Nutr 56, Supplement 2, 161

NGUYEN, D.N., OSTERGAARD, M.V., SANGILD, P.T., BERING, S.B. & CHATTERTON, D.: (2012) Transforming growth factor beta 2 (TGF-beta 2) effects on lipopolysaccharide (LPS)-induced cytokine secretion in developing intestinal epithelial cells PsIc1. Regulatory Peptides 177(1):S29-S29

(2010) PERSSON, B.A., LUND, M., FORSMAN, J., CHATTERTON, D.E.W., & ÅKESSON, T.:

Molecular evidence of stereo-specific lactoferrin dimers in solution. Biophys Chem 151(3): 187-189

(2010) Ercan, A.,  CUI, J. CHATTERTON, D.E.W., DEANE, K.D., HAZEN, M.M., BRINTNELL, W., O´DONNELL, C.I., DERBER, L.A., WEINBLATT, M.E., SHADICK, N.A., BELL, D.A., CAIRNS, E., SOLOMON, D.H., HOLERS, V.M., RUDD, P.M., & LEE, D,M.: IgG galactosylation aberrancy precedes disease onset, correlates with disease activity and is prevalent in autoantibodies in rheumatoid arthritis. Arthritis & Rheum, 62 (8), 2239-2248

(2006) CHATTERTON, D.E.W., SMITHERS, G., ROUPAS, P. & BRODKORB, A.: Bioactivity of β-Lactoglobulin and α-Lactalbumin – Technological Implications for Processing. International Dairy Journal, 16 (11) 1229-1240.

(2004) CHATTERTON, D.E.W., RASMUSSEN, J.T., HEEGAARD, C.W., SØRENSEN, E.S. & PETERSEN, T.E.: In vitro digestion of novel milk protein ingredients for use in infant formulas: Identification of new biological functions. Trends in Food Science & Technology, 15 (7-8): 373-383.

(2003): BRÜCK, W.M., KELLEHER, S.L, GIBSON, G.R., NIELSEN, K.E., CHATTERTON, D.E.W. & LŌNNERDAL, B.: rRNA probes used to quantify the effects of glycomacropeptide and α-lactalbumin supplementation on the predominant groups of intestinal bacteria of infant rhesus monkeys challenged with enteropathogenic Escherichia coli.  J Pediatr Gastroenterol Nutr, 37 (3): 273-280.

(2003): KELLEHER, S.L., CHATTERTON, D., NIELSEN, K. & LŌNNERDAL, B.: Glycomacropeptide and α-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. Am J Clin Nutr, 77:1261-1268.

ID: 6460167