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Primære forskningsområder

Research interests

Generally medicinal chemistry and the development of new methodology for the construction of compound classes of relevance to medicinal chemistry. Using these tools we are trying to develop new probes and tools that will help us to elucidate the underlying mechanisms responsible for the regulation of different pharmacological targets: Ion channels, enzymes and GPCR’s.

Please see group web-page for more informantion.

 - Member of the Horizon2020 “Click-It” consortium receiving 6 mio. Euro (2015-2020) where we are developing a new imaging technology based on in-vivo click-chemistry.

 - Member of the Marie Curie ETN "AlphaSy" consortium receiving 4.1 mio. Euro (2018-2022) where we are developing a new imaging agents to diagnose Parkisons disease at an early stage.

 - Coordinator of the ETN-EID project SAFER receiving 1.3 mio. Euro (2017-2021). SAFER aims to identify functionally Selective Agonists for the 5-HT2A Serotonin Receptor.

Mulige interessekonflikter

Founder and CSO @ Lophora (www.lophora.com)

Udvalgte publikationer

1. E-pub ahead of print

   Dark Classics in Chemical Neuroscience: NBOMes

   Poulie, Christian Bernard Matthijs, Jensen, Anders A., Halberstadt, A. & Kristensen, Jesper Langgaard, 28 okt. 2019, I : ACS Chemical Neuroscience.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

2. Udgivet

   Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine

   Clementson, S., Jessing, M., Pedersen, H., Vital, P. & Kristensen, Jesper Langgaard, maj 2019, I : Journal of the American Chemical Society. 141, 22, s. 8783-8786

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

3. Udgivet

   Detailed characterization of the in vitro pharmacological and pharmacokinetic properties of N-(2-hydroxybenzyl)-2,5-dimethoxy-4-cyanophenylethylamine (25CN-NBOH), a highly selective and brain-penetrant 5-HT2A receptor agonist

   Jensen, Anders A., McCorvy, J. D., Petersen, S. L., Bundgaard, C., Liebscher, G., Kenakin, T. P., Bräuner-Osborne, Hans, Kehler, J. & Kristensen, Jesper Langgaard, 2017, I : Journal of Pharmacology and Experimental Therapeutics. 361, 3, s. 441-453

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

4. Udgivet

   In situ generation of the Ohira-Bestmann Reagent from stable sulfonyl azide: scalable synthesis of alkynes from aldehydes

   Jepsen, T. H. & Kristensen, Jesper Langgaard, 12 sep. 2014, I : Journal of Organic Chemistry. 79, 19, s. 9423-9426 4 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt