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Primære forskningsområder

Research interests

Generally medicinal chemistry and the development of new methodology for the construction of compound classes of relevance to medicinal chemistry. Using these tools we are trying to develop new probes and tools that will help us to elucidate the underlying mechanisms responsible for the regulation of different pharmacological targets: Ion channels, enzymes and GPCR’s.

Please see group web-page for more informantion.

 - Member of the Horizon2020 “Click-It” consortium receiving 6 mio. Euro (2015-2020) where we are developing a new imaging technology based on in-vivo click-chemistry.

 - Member of the Marie Curie ETN "AlphaSy" consortium receiving 4.1 mio. Euro (2018-2022) where we are developing a new imaging agents to diagnose Parkisons disease at an early stage.

 - Coordinator of the ETN-EID project SAFER receiving 1.3 mio. Euro (2017-2021). SAFER aims to identify functionally Selective Agonists for the 5-HT2A Serotonin Receptor.

Udvalgte publikationer

1. Udgivet

   Enantioselective Total Synthesis of (+)-Dihydro-β-erythroidine

   Clementson, S., Jessing, M., Pedersen, H., Vital, P. & Kristensen, J. L., maj 2019, I : Journal of the American Chemical Society. 141, 22, s. 8783-8786

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

2. Udgivet

   Dual Nicotinic Acetylcholine Receptor α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies, and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts

   Crestey, F., Jensen, A. A., Soerensen, C., Magnus, C. B., Andreasen T., J., Peters, G. H. J. & Kristensen, J. L., 2018, I : Journal of Medicinal Chemistry. 61, s. 1719-1729

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

3. Udgivet

   Hallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl) ethylamino]methyl)phenol (25CN-NBOH), a novel N-benzylphenethylamine with 100-fold selectivity for 5-HT2A receptors, in mice

   Fantegrossi, W. E., Gray, B. W., Bailey, J. M., Smith, D. A., Hansen, M. & Kristensen, J. L., 2015, I : Psychopharmacology. 232, 6, s. 1039-47 9 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

4. Udgivet

   Metabolic fate of hallucinogenic NBOMes

   Leth-Petersen, S., Gabel-Jensen, C., Gillings, N., Lehel, S., Hansen, H. D., Knudsen, G. M. & Kristensen, J. L., 2016, I : Chemical Research in Toxicology. 29, 1, s. 96–100 5 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

5. Udgivet

   Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists

   Hansen, M., Phonekeo, K., Paine, J. S., Leth-Petersen, S., Begtrup, M., Bräuner-Osborne, H. & Kristensen, J. L., 7 jan. 2014, I : A C S Chemical Neuroscience. 5, 3, s. 243-249 8 s.

   Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt