Forskning ved Københavns Universitet - Københavns Universitet

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Lene Broeng Oddershede
Lene Broeng Oddershede

Professor

PRIVATE

Name:                                  Lene Broeng Oddershede

Title:                                     Professor

 

UNIVERSITY EDUCATION

PhD in physics from SDU, Odense, Denmark 1998.

Cand. Scient., physics and mathematics, SDU, Odense, Denmark 1995.

Bachelor of Science, physics and mathematics, SDU, Odense, Denmark 1992.

 

EMPLOYMENTS

Professor of physics, Niels Bohr Institute (NBI), University of Copenhagen, since 2015.

Group Leader for the Optical Tweezers Group, NBI, since 2003.

Associate professor (with tenure), NBI, 2003-2014.

Assistant professor, 1998-2003, experimental biological physics. Constructing the optical tweezers laboratory at the Niels Bohr Institute.

Visiting graduate student, James Frank Institute, University of Chicago, USA, 1996-1997.

 

AWARDS

  • Elite Research Price, Danish public research prize, 2015.
  • Member of AcademiaNet, European database of excellent female researchers, 2015.
  • Member of the Royal Danish Academy of Sciences and Letters, 2014.
  • Silver medal of the Royal Danish Academy of Sciences, 2011
  • CeNS Publication Award for an outstanding publication in the field of nanoscience (PRL vol.106 p.048103, 2011), issued by the Center for NanoScience, LMU, 2011.
  • Danish Optical Society Award for Young Investigators, 2003.
  • Danish Physical Society award for best poster in 1994, 1995 and 2003.

 

SCIENTIFIC EXPERTISE

The key research expertise of LBO is at the vibrant interface between physics, biology and medicine where she has significant experience in establishing and leading major interdisciplinary research collaborations.  LBO is trained as an experimental physicist and constructed the first optical manipulation facility in Scandinavia. She is expert on mechanics of living matter, from the single molecule to the tissue level with a current focus on unraveling the biomechanics of cancer cells, stem cells and developing organs. She is a pioneer in exploring and understanding the interaction between nanoparticles, light and living matter and has invented a novel cancer therapy based on plasmonic nanoparticles.

 

LEADERSHIP EXPERIENCE

  • April 2015 – March 2021 Center leader of Danmarks Grundforskningsfond StemPhys Center of Excellence (granted 60 mio kr).
  • DNRF leadership course (2 modules) February 2016.
  • April 2015 – March 2018 PI of Novo Nordisk Foundation Synergy Grant (14.5 mio kr) for the LANTERN project.
  • July 2014 – July 2017 PI of FNU Research Project 2 (granted 6 mio kr).
  • July 2008 - July 2013 Leader of MolPhysX University of Copenhagen Excellence program (granted 20 mio kr).
  • 2012-2014 PI of Lundbeck center for active nanoparaticles (granted 2.5 mio kr). This center encompassing 3 faculty members, 3 temporary scientists.
  • Since 2006 Vice-group leader of the Biocomplexity section at the Niels Bohr Institute, University of Copenhagen (~40 scientists).
  • Since 2003 Group Leader of the Optical Tweezers Group at the Niels Bohr Institute, University of Copenhagen. The group comprises approximately 20 scientists.

 

AWARDED RESEARCH GRANTS

  • 2015-2021 Danmarks Grundforskning Center of Excellence ‘StemPhys: Stem Cell Decision making’, 60 mio Dkr, PI: LBO.
  • 2015-2018 Novo Nordisk Foundation Synergy Grant ‘LANTERN: Laser activated nanoparticles for tumor elimination’, 14.5 mio Dkr, PI: LBO.
  • 2014-2017 FNU Research Project 2 ‘Force mapping during cancer cell division and invasion’, 6 mio Dkr, PI: LBO.
  • 2012-2014 Lundbeckfonden Center for active nanoparticles, 2.5 mio Dkr, PI: LBO.
  • 2010-2013 Lundbeckfonden Center for complexity of amyloid formation, 5 mio Dkr, PI: M. Høgh Jensen, LBO one of 3 co-applicants.
  • 2010-2015 Lundbeckfonden Center for biomembranes in nanomedicine, 36 mio Dkr, PIs: D. Stamou and U. Gether, LBO one of 7 co-applicants.
  • 2009 FNU Equipment, Danish research councils, 1.2 mio Dkr, PI: LBO.
  • 2008-2013 Excellence Center at University of Copenhagen, 20 mio Dkr, PI: LBO.
  • 2004-2009 BioNET a Villum Kann Rasmussen Center, 25 mio Dkr, PI: M. Høgh Jensen, LBO one of 9 co-applicants.
  • 2006-2008 FNU Rammebevilling Danish Research Councils, 600.000 Dkr, PI: LBO.
  • 2006 Carlsbergfoundation, Equipment 1 mio Dkr, PI: LBO.
  • 1999-2004 FREJA grant Danish Research Councils, 6 mio Dkr, PI K. Berg-Sørensen, LBO co-applicant.
  • 1995-1998 PhD fellowship from Danish Research Councils, applicant: LBO.

 

ASSESSMENT OF RESEARCH APPLICATIONS AND PROGRAMS

  • Novo Nordisk Fonden, evaluator of all grant types, strategic as well as open competition.
  • HFSP, Human Frontier Science Program, an international highly competitive program accepting applications from the entire World and with an emphasis on scientific excellence and mobility. LBO is a member of the fellowship assessment committee (2016-2018).
  • Exploratory Pree-Seed, Novo Nordisk Foundation, LBO is a member of the program committee for assessment of applications from the Nordic countries (2016-2018).
  • Evaluator of ERC applications at the starter, consolidator and advanced levels.
  • Evaluator of research applications from the Norwegian, Dutch, and French research councils.
  • Consultant for Alexander van Humboldt Stiftung, Germany.

 

CURRENT MEMBERSHIPS

  • Member of the Royal Danish Academy of Sciences and Letters (2014-)
  • AcademiaNet,European database of excellent female researchers, (2015-)
  • Niels Bohr Institute research committee (2017-2019)
  • Danish National Committee for Biophysics (2007-)
  • American Biophysical Society (1999-)
  • KIF (network of female physicists) (1998-)
  • Dansk Fysisk Selskab (1996-)

PUBLICATIONS

A total of ~150 publications. Of these ~ 110 are published in major international refereed scientific journals, 5 are under review, ~20 are conference proceedings, and 12 are popular / didactical papers. Afull publication list is enclosed. 2 patents.

 

CITATIONS

Total number of citations: >6350. H-index: 42.

 

TRANSLATION OF BASIC RESEARCH TO INNOVATION:

Founder and Director of ‘Lantern ApS’, CVR 39012839.

1 patent + 1 patent application in progress.

 

TEACHING

LBO has been responsible for the following courses at the Niels Bohr Institute

  • Introduction to Biophysics (bachelor course).
  • Cell Mechanics (graduate/masters course)
  • Single Molecule Biophysics (graduate/masters course), evaluated as an ‘A course’ by the students.
  • Biophysics of cells and single molecules (graduate/masters course), evaluated as an ‘A course’ by the students.
  • Cross-institutional course in molecular biophysics (PhD course)

SUPERVISION

LBO has been the main supervisor of ~45 master students and 26 graduate students. In addition, she has been the supervisor/mentor of ~15 postdocs.

INVITED TALKS

A total of more than 130 presentations at international research conferences, summer schools, and institute colloquia, in the latter years often as ‘plenary speaker’. In addition to the research based presentations, since 2019 she has also been an invited speaker in more political fora as, e.g., at the World Economic Forum (WEF) in Davos and at international research funding meetings.

REFEREEING

LBO regularly referees for the Nature journals, for the ACS journals, for the OSA and APS journals, and for Cell journals.

 

Published in international peer reviewed journals

1. Plasmonic Material Engineering for Targeted Therapeutics. C.D. Florentsen, G.S. Moreno-Pescador, A. Kjær, L. B. Oddershede, P.M. Bendix. Advanced Optical Materials, 2000616-(1-17) (2020).

2. P. Purohit, A. Samadi, P.M. Bendix, J.J. Laserna, L.B. Oddershede. Optical trapping reveals difference in dielectric and optical properties of copper nanoparticles compared to their oxides and ferrites Scientific Reports, vol 10, p. 1-10 (2020).

3. L. Jauffred, A. Samadi, H. Klingberg, P.M. Bendix, L. B. Oddershede. Plasmonic Heating of Nanostructures. Chemical Reviews, vol. 19, Issue 13, p. 8087-8130 (2019).

4. M. Simón, K. Norregaard, J. T. Jørgensen, L. B. Oddershede, A. Kjaer. Fractionated photothermal therapy in a murine tumor model: comparison with single dose. International Journal of Nanomedicine, vol. 14, p.5369—5379 (2019).

5. Y. He, K. Laugesen, D. Kamp, S.A. Sultan, L.B. Oddershede, L. Jauffred. Effects and side effects of plasmonic photothermal therapy in brain tissue. Cancer Nanotechnology, vol 10, Issue 1, p. 1-11 (2019).

6. C.D. Florentsen, A-K. V.West, H.M.D. Danielsen, S. Semsey, P.M. Bendix, L. B. Oddershede. Quantification of Loading and Laser-Assisted Release of RNA from Single Gold Nanoparticles. Langmuir, vol. 34 (49), p. 14891–14898 (2018).

7. A. Christensen, A.-K. V. West, L. Wullkopf, J. T. Erler, L. B. Oddershede and J. Mathiesen. Friction-limited cell motility in confluent monolayer tissue. Phys. Biol., vol. 15 p. 066004 (2018).

8. L. Wullkopf, A-K. V.West, N. Leijnse, T. R. Cox, C. D. Madsen, L. B. Oddershede, J. T. Erler. Cancer cell ability to mechanically adjust to extracellular matrix stiffness correlates with their invasive potential. Mol Biol Cell.,  vol. 29, p. 2378-2385 (2018).

9. A. H. Montoto, R. Montes, A. Samadi, M. Gorbe, J. Terrés, R. Cao-Milán, E. Aznar, J. Ibañez, R. Masot, M. D. Marcos, M. Orzáez, F. Sancenón, L. B. Oddershede, and R. Martínez-Máñez. Gold Nanostars Coated with Mesoporous Silica Are Effective and Nontoxic Photothermal Agents Capable of Gate Keeping and Laser-Induced Drug Release. ACS Appl. Mater. Interfaces, vol. 10, p. 27644−27656 (2018).

10. J.T. Jørgensen, K. Norregaard, M.S. Martin, L.B. Oddershede, A. Kjaer. Non-invasive Early Response Monitoring of Nanoparticle-assisted Photothermal Cancer Therapy Using 18F-FDG, 18F-FLT, and 18F-FET PET/CT Imaging. Nanotheranostics vol. 2, p. 201-2010 (2018).

11. A. Samadi, H. Klingberg, L. Jauffred, A. Kjaer, P.M. Bendix, L.B. Oddershede. Platinum nanoparticles: a non-toxic, effective and thermally stable alternative plasmonic material for cancer therapy and bioengineering. Nanoscale, vol. 10, p. 9097 (2018).

12. T. Stangner, T. Dahlberg, P. Svenmarker, J. Zakrisson, K. Wiklund, L.B. Oddershede, M. Andersson. Cooke-Triplet tweezers: more compact, robust, and efficient optical tweezers. Optics Letters vol. 43, p. 1990-1993 (2018).

13. A. Christensen, A.-K. V. West, L. Wullkopf, J. T. Erler, L. B. Oddershede and J. Mathiesen. Friction-limited cell motility in confluent monolayer tissue. Phys. Biol. vol. 15 p. 066004 (2018).

14. A. Bahadori, G. Moreno-Pescador, L.B. Oddershede, P.M. Bendix. Remotely controlled fusion of selected vesicles and living cells: a key issue review. Rep. Prog. Phys vol. 81 p. 032602 (2018).

15. A. Bahadori, G. Moreno-Pescador, L.B. Oddershede, P.M. Bendix. Remotely controlled fusion of selected vesicles and living cells: a key issue review. Rep. Prog. Phys., vol. 81 p. 032602-(1-25) (2018).

16. A. Samadi, P.M. Bendix, L.B. Oddershede. Optical manipulation of individual strongly absorbing platinum nanoparticles. Nanoscale, vol. 9 p. 18449-18455 (2017).

17. K.R. Rosholm, N. Leijnse, A. Mantsiuo, V. Tkach, S.L. Pedersen, V.F. Wirth, L.B. Oddershede, K.J. Jensen, N.S. Hatzakis, P.M. Bendix, A. Callan-Jones, D. Stamou. Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells. Nature Chemical Biology, vol. 13 p. 724-729 (2017).

18. L. Jauffred, R. Munk-Vejborg, K.S. Korolev, S. Brown, L.B. Oddershede. Chirality in microbial biofilms is mediated by close interactions between the cell surface and the substratum. ISME Journal, Nature Publ Group, vol. 11 p. 1688-1701 (2017).

19. K. Norregaard, R. Metzler, C.M. Ritter, K. Berg-Sorensen, L.B. Oddershede. Manipulation and motion of organelles and single molecules in living cells. Chemical Reviews, vol. 117, p. 4342-4375 (2017).

20. A.-K. V. West, L. Wullkopf, A. Christensen, N. Leijnse, J.M. Tarp, J. Mathiesen, J.T. Erler, L.B. Oddershede. Dynamics of cancerous tissue correlates with invasiveness. Scientific Reports, vol. 7 p. 43800-(1-11) (2017).

21. A. Bahadori, L.B. Oddershede, P.M. Bendix. Hot-nanoparticle-mediated fusion of selected cells. Nano Research, vol. 10, p. 2034-2045 (2017).

22. A. Bahadori, L.B. Oddershede, P.M. Bendix. Optically controlled and selective fusion of cells and vesicles using plasmonic nano-heaters. Light Robotics - Structure-mediated Nanobiophotonics, Elsevier, ISBN: 9780702070969 (2017).

23. C.M. Ritter, J. Mas, L. Oddershede, K. Berg-Sorensen. Quantifying force and viscoelasticity inside living cells using an active-passive calibrated optical trap. Optical Tweezers: Methods and Protocols, Methods in Molecular Biology, vol. 1486 p. 513-536, DOI 10.1007/978-1-4939-6421-5_20, Springer (2017).

24. J. Tranekjaer Joergensen, K. Norregaard, P. Tian, P.M. Bendix, A. Kjaer, L.B. Oddershede. Single Particle and PET-based platform for identifying optimal plasmonic nano-heaters for photothermal cancer therapy. Scientific Reports, vol. 6 p. 30076-(1-10) (2016).

25. L. Jauffred, S. Mohammad-Reza Taheri, R. Schmitt, H. Linke, L.B. Oddershede.

Optical Trapping of Gold Nanoparticles in Air. Nano Letters, vol. 15 p. 4713-4719 (2015).

This paper is also featured at Nanowerk.com and on the Women in Nanoscience blog

26. A. Rørvig-Lund, A. Bahadori, S. Semsey, P.M. Bendix, L.B. Oddershede. Vesicle Fusion Triggered by Optically Heated Gold Nanoparticles. Nano Letters, vol. 15 p. 4183-4188 (2015).

27. H. Klingberg, S. Loft, L.B. Oddershede, Peter Møller. Influence of flow, shear stress and adhesion molecule targeting on gold nanoparticle uptake in human endothelial cells.

Nanoscale, vol. 7 p. 11409-11419 (2015).

28. A. Kosmrlj, P. Cordsen, A. Kyrsting, D.E. Otzen, L.B. Oddershede, M.H. Jensen. A monomer-trimer model supports intermittent glucagon fibril growth. Scientific Reports, vol. 5 p. 9005-(1-6) (2015).

29. N. Leijnse, L.B. Oddershede, P.M. Bendix. An updated look at actin within filopodia. Cytoskeleton, vol.72 p.71-79 (2015).

30. N. Leijnse, L.B. Oddershede, P.M. Bendix. Dynamic buckling of actin within filopodia.Communicative and Integrative Biology, vol.8 p. e1022010-(1-3) (2015).

31. N. Leijnse, L.B. Oddershede, P.M. Bendix. Helical buckling of actin inside filopodia generates traction. PNAS, vol. 112 p. 136-141 (2015).

32. L.B. Oddershede, Voices of Chemical Biology, Nature Chemical Biology, vol. 11 p. 378-379, 446-447, 752-753 (2015).

33. H. Klingberg, L.B. Oddershede, K. Loeschner, E.H. Larsen, S. Loft, P. Møller. Uptake of gold nanoparticles in primary human endothelial cells. Toxicology research, vol. 4 p.655-666 (2015).

34. N.S. Rossen, J.M. Tarp, J. Mathiesen, M.H. Jensen, L.B. Oddershede. Long-range well-ordered vorticity patterns arising from cell divisions in a cellular monolayer. Nature Communications, vol. 5 p. 5720 (1-7) (2014).

35. K. Norregaard, M. Andersson, P.E. Nielsen, S. Brown, L.B. Oddershede. Tethered particle analysis of supercoiled circular DNA using PNA handles. Nature Protocols, vol. 9 p. 2206 (2014).

36. D. Ott, S.N.S. Reihani, L.B. Oddershede. Simultaneous three-dimentional tracking of indi- vidual signals from multi-trap optical tweezers using fast and accurate photodiode detection. Optics Express, vol. 22 p. 23661-23672 (2014).

37. Y.F. Baroji, L.B. Oddershede, S.N.S. Reihani, P.M. Bendix. Fluorescent quantification of size and lamellarity of membrane nanotubes. European Biophysics Journal, vol. 43 p. 595-602 (2014).

38. L. Jauffred, A. Kyrsting, E.C. Arnspang, S.N.S. Reihani, L.B. Oddershede. Sub-diffraction positioning of a two-photon excited and optically trapped quantum dot. Nanoscale, vol. 6 p. 6997-7003 (2014).

39. D. Ott, S.N.S. Reihani, L.B. Oddershede. Crosstalk elimination in the detection of dual-beam optical tweezers by spatial filtering. Review of Scientific Instruments, vol. 85 p. 053108-(1-8) (2014).

40. H. Ma, P. Tian, J. Pello, P.M. Bendix, L.B. Oddershede. Heat generation by irradiated complex composite nanostructures. Nano Letters, vol. 14 p. 612-619 (2014).

41. K. Norregaard, L. Jauffred, K. Berg-Sorensen, L.B. Oddershede. Optical manipulation of single molecules  in  the  living cell. PCCP, vol. 16 p. 12614-12624 (2014).

42. P.M. Bendix, L. Jauffred, K. Norregaard, L.B. Oddershede. Optical trapping of nanoparticles and quantum dots. IEEE J  of  Selected  Topics  in  Quantum Electronics, vol. 20 p. 4800112-(1- 12) (2014).

43. K. Norregaard, M. Andersson, K. Sneppen, P.E. Nielsen, S. Brown, L.B. Oddershede. Effect of supercoiling on the lambda switch. Bacteriophage vol. 4 p. e27517-(1-5) (2014).

44. R.B. Ettlinger, M.A. Sorensen, L.B. Oddershede. Force Spectroscopy of DNA and RNA: Structure and kinetics from single-molecule experiments. Nucleic Acid Nanotechnology, Nucleic Acids and Molecular Biology vol.29, Springer Verlag, DOI: 10.1007/978-3-642-38815-6-2 p.23- 52 (2014).

45. T.E. Rasmussen, L. Jauffred, J. Brewer, S. Vogel, E.R. Torbensen, B.C. Lagerholm, L. Odd- ershede, E.C. Arnspang, Single Molecule Applications of Quantum Dots, Journal of Modern Physics, vol.4 p. 27-42 (2013) .

46. T. Jakociunas, M.D. Jordo, M.A. Mebarek, C.M. Bunner, J. Verhain-Hansen, L.B. Oddershede,

G. Thon, Subnuclear relocalization and silencing of a chromosomal region by an ectopic rDNA repeat, PNAS, vol.110 p. E4465-E4473 (2013).

47. D. Ott, P.M. Bendix, L.B. Oddershede. Revealing hidden dynamics within living soft matter, ACS Nano, vol.7 p. 8333-8339 (2013).

48. K. Norregaard, M. Andersson, K. Sneppen, P.E. Nielsen, S. Brown, L.B. Oddershede, DNA supercoiling enhances cooperativity and efficiency of an epigenetic switch, PNAS, vol.110 p.17386- 17391 (2013).

49. J. Mas, A.C. Richardson, S.N.S. Reihani, L.B. Oddershede, K. Berg-Sorensen, Quantitative determination of optical trapping strength and viscoelastic moduli inside living cells, Physical Biology, vol.10 p. 046006-(1-10) (2013).

50. S.B. Nielsen, F. Macchi, S. Raccosta, A.E. Langkilde, L. Giehm, A. Kyrsting, A.S.P. Svane, M. Manno, G. Christiansen, N.C. Nielsen, L.Oddershede, B. Vestergaard, D.E. Otzen, Wildtype and A30P mutant alpha-synuclein form different fibril structures, PLoS1, vol.8, p. e67713-(1- 13) (2013).

51. M. Eriksen, P. Hovarth, M.A. Sorensen, S. Semsey, L.B. Oddershede, L. Jauffred, A novel com- plex: A quantum dot conjugated to an active T7 RNA polymerase, Journal of Nanomaterials, vol.2013, p. 468105-(1-9) (2013).

52. P. Ramesh, Y.F. Baroji, S.N.S. Reihani, D. Stamou, L.B. Oddershede, P.M. Bendix, FBAR Syndapin  recognizes and stabilizes highly curved tubular membranes in a concentration de- pendent manner, Scientific Reports, Nature Publishing Group, vol.3, p.1565-(1-6) (2013).

53. J.-H. Jeon, N. Leijnse, L.B. Oddershede, R. Metzler, Anomalous diffusion and power-law re- laxation of the time averaged mean square displacement in worm-like micellar solution, New J. Phys. vol.15 p.045011-(1-16) (2013).

54. A. Kyrsting, P.M. Bendix, L.B. Oddershede, Mapping 3D focal intensity exposes the stable trapping positions of single nanoparticles, Nano Letters vol.13 p.31-35 (2013).

55. L.B. Oddershede. Force probing of individual molecules inside the living cell is now a reality. Nature Chemical Biology, vol 8 p.879-886 (2012)

56. H. Ma, P.M. Bendix, L.B. Oddershede Large-Scale Orientation Dependent Heating from a Single Irradiated Gold Nanorod. Nano Letters vol.12 p.3954-3960 (2012)

57. N. Leijnse, J.-H. Jeon, S. Loft, R. Metzler, L.B. Oddershede. Diffusion inside living human cells. European Physical Journal ST vol.204 p.75-84 (2012)

58. J. Tholstrup, L.B. Oddershede, M.A. Sorensen mRNA pseudoknot like structures can act as ribosomal roadblocks. Nucleic Acids Research vol.40 p.303-313 (2012)

59. P.M. Bendix, L.B. Oddershede. Expanding the optical trapping range of lipid vesicles to the nano-scale. Nano Letters vol.11 p. 5431-5437 (2011).

60. P. Gross, N. Laurens, L.B. Oddershede, U. Bockelmann, E.J.G. Peterman, G.J.L. Wuite. Quan- tifying how DNA stretches, melts and changes twist under tension. Nature Physics vol. 7 p.731-736 (2011).

61. N.S. Rossen, A.J. Hansen, C. Selhuber-Unkel, L.B. Oddershede. Arachidonic Acid Randomizes Endothelial Cell Migration and Regulates Adhesion and Migration. PLoS ONE vol. 6 p.e25196 (2011).

62. S.N.S. Reihani, A.C. Richardson, L.B. Oddershede. Significant improvements of optical traps by tuning standard water immersion objectives. Journal of Optics vol 13 p.105301 (6pp) (2011).

63. A. Kyrsting, P.M. Bendix, D.G. Stamou, and L.B. Oddershede. Heat Profiling of Three- Dimensionally Optically  Trapped   Gold Nanoparticles  using  Vesicle  Cargo  Release. Nano Letters,  vol 11 p.888-892 (2011).

64. J.H. Jeon, V. Tejedor, S. Burov, E. Barkai, c. Selhuber, K. Berg-Sørensen, L.B. Oddershede, R. Metzler. In vivo anomalous diffusion and weak ergodicity breaking of lipid granules. Physical Review Letters, vol 106 p. 048103 (2011).

65. M. Andersson, F. Czerwinski, L.B. Oddershede. Optimizing active and passive calibration of optical tweezers. Journal of Optics vol. 13 p. 044020 (2011)

66. F. Czerwinski, L.B. Oddershede. TimesSeriesStreaming.vi: LabVIEW program for reliable data streaming of large analog time series. Computer Physics Communications, vol. 30 p.349-358 (2011)

67. P.C.F. Mller and L.B. Oddershede. Small-Scale Nonequilibrium Systems. Chapter 7 in Hand- book of Nanophysics ’Principles and Methods’, CPC Press, Taylor & Francis Group, ISBN 978-1-4200-7540-3  (2011)

68. V.V. Albert, R.T. Chancey, L.B. Oddershede, F.E. Harris. Fragmentation of Fullerenes. J.R. Sabin, chapter 26 in Handbook of Nanophysics ’Clusters and Fullerenes’, CPC Press, Taylor & Francis Group, ISBN 978-1-4200-7554-0 (2011)

69. L. Jauffred and L.B. Oddershede. Two-photon quantum dot excitation during optical trapping. Nano Letters, vol. 10 p.1927-1930 (2010)

70. O. Otto, F. Czerwinski, J.L. Gornall, G. Stober, L.B. Oddershede, U.F. Keyser. Real-time Par- ticle Tracking at 10,000 fps using Optical Fiber Illumination. Optics Express, vol.18 p.22722- 22733 (2010)

71. P.M. Bendix, S.N.S. Reihani and L.B. Oddershede. Direct measurements of heating by electromagnetically trapped gold nanoparticles on supported lipid bilayers. ACS Nano, vol. 4 p.2256-2262 (2010)

72. V. Tejedor, O. Benichou, R. Voituriez, R. jungmann, F. Simmel, C. Selhuber-Unkel, L.B. Oddershede and R. Metzler. Quantitative  analylsis  of   single particle trajectories: mean maximal excursion method. Biophysical Journal, vol. 98 p.1364-1372 (2010)

73. M. Fischer, A. Richardson, S.N.S. Reihani, L.B. Oddershede and K. Berg-Sørensen. Active- passive calibration of optical tweezers in viscoelastic media. Review of Scientific Instruments, vol. 81 p.015103-(1-10) (2010)

74. P.C.F. Mller and L.B. Oddershede. Quantification of droplet deformation by electromagnetic trapping. EPL vol. 88 p.48005 (1-6) (2009)

75. F. Czerwinski, A.C. Richardson and L.B. Oddershede. Quantifying Noise in Optical Tweezers by Allan Variance. Optics Express vol. 17 p.13255-13269 (2009)

76. T. Winther, L. Xu, K. Berg-Srensen, S. Brown and L.B. Oddershede. Effect of energy metabolism on protein motility in baceterial outer membranes. Biophysical Journal, Biophysical Journal vol. 97 p.1-8 (2009)

77. T. Winther and L.B. Oddershede. Effect of antibiotics and antimicrobial peptides on single protein motility. Current Pharmaceutical Biotechnology vol.10 p. 486-493 (2009)

78. S.N.S. Reihani and L.B. Oddershede. Confocal microscopy of thick specimens. Journal of Biomedical Optics, vol. 14 p.030513 (2009

79. C. Selhuber-Unkel, P. Yde, K. Berg-Srensen and L.B. Oddershede. Variety in intracellular diffusion during the cell cycle. Physical Biology, vol. 6, p. 025015 (2009)

80. L. B. Oddershede, Optical Tweezers Techniques, Chapter in Handbook of Molecular Biophysics, Wiley ISBN 978-3-527-40702-6, p.195-214 (2009).

81. A.C. Richardson, S.N.S. Reihani and L.B. Oddershede. Non-harmonic potential of a single beam optical trap. Optics Express, vol. 16, p.15709-15717 (2008)

82. L. Jauffred, A.C. Richardson and L.B. Oddershede. Three-dimensional optical control of indi- vidual quantum dots. Nano Letters, vol.8, p.3376-3380 (2008)

83. C. Selhuber-Unkel, I. Zins, O. Schubert, C. Soennichsen and L.B. Oddershede. Quantitative optical trapping of single gold nanorods. Nano Letters, vol. 8, p. 2998-3003 (2008)

84. M. B. Rasmussen, L.B. Oddershede, H. Siegumfeldt. Optical tweezers cause physiological damage to E. coli and Listeria bacteria. Applied and Environmental Microbiology, vol.74 p.2441-2446 (2008)

85. L. Bo sanac, T. Aabo, P.M. Bendix, and L. Oddershede. Efficient Optical Trapping and Visu- alization of Silver Nanoparticles. Nano Letters, vol. 8 p.1486-1491 (2008)

86. T.M. Hansen, S.N.S. Reihani, L. Oddershede, and M. Sørensen. Correlation between mechan- ical strength of RNA pseudoknots and ribosomal frameshifting. PNAS, vol.104, p.5830-5835 (2007)

87. S.N.S. Reihani and L. Oddershede. Optimizing immersion media refractive index improves optical trapping by compensating spherical aberrations. Optics Letters, vol.32, p.1998-2000 (2007)

88. L. Jauffred, T.H. Callisen, L.B. Oddershede. Visco-elastic Membrane Tethers extracted from Escherichia coli by Optical Tweezers. Biophysical journal, vol. 93, p.1-8 (2007)

89. S.F. Tolic-Nrrelykke, M.B. Rasmussen, F.S. Pavone, K. Berg-Srensen, and L.B. Oddershede. Stepwise bending of DNA by a single TATA-box Binding Protein. Biophysical journal, vol. 90 p.3694-3703 (2006)

90. J.K. Dreyer, K. Berg Srensen, and L. Oddershede. Quantitative approach to small-scale nonequilibrium systems. Phys. Rev. E, vol. 73, 051110 (2006)

91. E.-L. Munteanu, A.L. Olsen, I. Tolic-Nørrelykke, H. Flyvbjerg, L. Oddershede, and K. Berg- Sørensen. Quantitative studies of subdiffusion in living cells and actin networks. Biophysical Review and Letters, vol. 1, no.4, p.411-422 (2006)

92. P.M. Hansen, V.K. Bhatia, N. Harrit, and L. Oddershede. Expanding the optical trapping range of gold nanoparticles. Nano Letters, vol. 5 p.1937-1942 (2005)

93. P.M. Hansen, J.K. Dreyer, J. Ferkinghoff-Borg, and L. Oddershede. Novel optical and statistical methods reveal colloid-wall interactions inconsistent with DLVO and Lifshitz theories. Journal of Colloid and Interface Science, 287 p.561-571 (2005)

94. J.K. Dreyer, K. Berg-Sørensen,and L. Oddershede. Improved Axial Position Detection in Op- tical Tweezers Measurements. Applied Optics vol. 43, issue 10 p. 1991-1996 (2004)

95. J.A. ˚Astrøm, R.P. Linna, J. Timonen, P.F. Møller and L. Oddershede. Exponential and Power- law mass Distributions in Brittle Fragmentation. Physical Review E. vol. 70, p. 026104-(1-7) (2004)

96. Iva Marija Tolic-Nørrelykke, E.-L. Munteanu, G. Thon, L. Oddershede and K. Berg-Sørensen. Anomalous diffusion in living yeast cells. Physical Review Letters vol. 93 p. 078102-(1-4) (2004)

97. K. Berg-Sørensen, L. Oddershede, E.L. Florin, and H. Flyvbjerg. Unintended Filtering in Typical Photo-diode Detection System for Optical Tweezers. Journal of Applied Physics vol. 93, no. 6, p. 3167-3176 (2003).

98. L. Oddershede, H. Flyvbjerg, and K. Berg-Sørensen. Single-molecule experiment with optical tweezers: improved analysis of the diffusion of the lambda-receptor in E. Coli’s outer membrane.

J. Phys. Condens. Matter vol. 15, p. S1737-S1746 (2003)

99. R. Chancey, L. Oddershede, F. E. Harris, and J. R. Sabin Fragmentation of Fullerenes. Phys. Rev. A vol. 67, p.043203-(1-7) (2003)

100. L. Oddershede, J.K. Dreyer, S. Grego, S. Brown, and K. Berg-Sørensen. The motion of a single molecule, the lambda-receptor, in the bacterial outer membrane. Biophys. J. vol. 83, p. 3152-3161 (2002)

101. U. Quaade and L. Oddershede Electrochemical etching of tips for scanning tunneling microscopy reveals singularity. Europhys. Lett. vol. 57, p. 611-617 (2002)

102. Oddershede, S. Grego, S.F. Nørrelykke and K. Berg-Sørensen. Optical tweezers: a probe for biological surfaces. Probe Microscopy vol. 2, p. 129-137 (2001)

103. L. Oddershede and S.R. Nagel. Singularity During the Onset of an Electrohydrodynamic Spout. Phys. Rev. Lett. vol. 85, p. 1234-1237 (2000)

104. L. Oddershede,  A. Meibom,   J. Bohr.  Scaling  Analysis of  Meteorite Shower Mass Distributions.  Europhys. Lett. vol. 43, p 598-604 (1998)

105. A. Kuhle, A.H. Sorensen, L. B. Oddershede, H. Busch, L. Theil Hansen, and J. Bohr. Scaling in patterns produced by cluster deposition. Z. Phys. D. vol. 40, 523-525 (1997)

106. L. Oddershede and J. Bohr. Self-Organized Structures in Magnetic Liquids. Physica Scripta vol.T67, 73-79 (1996)

107. L. Oddershede, P. Dimon, J. Bohr. Self-Organized Criticality in Fragmenting. Phys. Rev. Let., vol. 71 p. 3107-3110 (1993).

Patents

108. D. Ott, S.N.S. Reihani, L.B. Oddershede. A detection system for an optical manipulation sys- tem for manipulating micro-particles or nano-particles of a sample by means of at least two optical traps. PA 2014 70097, 1400006471 (2014).

109. L.B. Oddershede, A. Kjær. Lipid-coated nanoparticles for plasmonic resonance cancer therapy. PA 2018 70678, PCT/DK2019/050317.

Proceedings

110. A. Samadi, L. Jauffred, H. Klingberg, P.M. Bendix, L. B. Oddershede. Optical control of strongly absorbing nanoparticles and their potential for photothermal treatment. Proc. of Spie, vol. 10935, p. 109351A-1 (2019).

111. A. Samadi, M. Wang, Y. Yang, L.B. Oddershede. Optical trapping of individual magnetic nanoparticles. Proc. SPIE 10723, Optical Trapping and Optical Micromanipulation SC, vol. 10723, p. 107230E-(1-10), doi: 10.1117/12.2324124 (2018).

112. L.B. Oddershede, A. Bahadori, P.M. Bendix. Optical manipulation of hot nanoparticles can mediate selected cell fusion. Proc. SPIE 10252, Optical Manipulation Conference, vol. 10252, p.1025207(1-3); doi:10.1117/12.2270424 (2017).

113. A. Bahadori, A.R. Lund, S. Semsey, L.B. Oddershede, P.M. Bendix. Controlled cellular fusion using optically trapped plasmonic nano-heaters. Proceedings of SPIE, vol. 9922 p. 1-10 (2016).

114. C.M. Ritter, J.M. Brickman, L.B. Oddershede. Optical quantification of forces at play during stem cell differentiation. Proceedings of SPIE, vol. 9764 p. 97640J-(1-9) (2016).

115. R.K. Schmitt, L. Jauffred, S. Mohammad-Reza Taheri, H. Linke, L.B. Oddershede, Optical trapping of gold aerosols. Proceedings of SPIE vol 9548 p.95480F-1(2015)

116. D. Ott, S.N.S. Reihani, L.B. Oddershede. Enabling accurate photodiode detection of multiple optical traps by spatial filtering. Proceedings of SPIE vol. 9164 p. 916411-(1-6) (2014).

117. H. Ma, P.M. Bendix, L.B. Oddershede, Measurements of extreme orientation-dependent tem- perautre increase around an irradiated gold nanorod. Proc. of SPIE Vol. 8458 84581R-(1-10) (2012).

118. A. Kyrsting, P.M. Bendix, L.B. Oddershede, Photothermal heating of optically trapped gold nanoparticles quantified using controlled vesicle cargo release. Proc. of SPIE Vol. 8458 84580X- (1-8) (2012).

119. L. Jauffred, M. Sletmoen, F. Czerwinski, and L. Oddershede. Quantum dots as handles for optical manipulation. SPIE proceeding, vol. 7762, number 776226 (2010)

120. F. Czerwinski, A.C. Richardson, C. Selhuber-Unkel and L.B. Oddershede. Quantifying and pinpointing sources of noise in optical tweezers experiments Proc. of SPIE vol.7400, 740004-1– 740004-9 (2009)

121. M. Fischer, A. Richardson, S. Nader S. Reihani, L.B. Oddershede, K. Berg-Sørensen. Validation of calibration method in complex media. SPIE proceedings (2008)

122. A. Richardson, S.N.S. Reihani, L.B. Oddershede Extending the lateral trapping force of optical tweezers. SPIE proceedings, vol. 6644, p.664420-1-9 (2007)

123. S.N.S. Reihani and L.B. Oddershede Improving optical trapping in the axial direction and a continuous change of the optimal trapping depth. SPIE proceedings, vol. 6644, p.664421-1-8 (2007)

124. T.M. Hansen, N. Reihani, and L. Oddershede Combining optical tweezers and micropipettes for DNA stretching: Elasticity of micropipette crucial. NATO Science Series, vol. 232, p.163-173, Springer (2006)

125. N. Reihani, L. Bosanac, T.M. Hansen, and L. Oddershede Stretching short DNA tethers using optical tweezers. SPIE proceedings, vol. 6326 p.21-28 (2006)

126. A.C. Richardson, N. Reihani, L. B. Oddershede Combining confocal microscopy with precise force-measuring optical tweezers. SPIE proceedings, vol. 6326 p.28-38 (2006)

127. P.M. Hansen and L.B. Oddershede Optical Trapping Inside Living Organisms SPIE proceedings vol. 5930 p.1-9, august (2005)

128. Kirstine Berg-Sørensen, Lene Oddershede and Henrik Flyvbjerg Optical Tweezers as a Tool of Precision: Single-Molecule Mobility as Case Study SPIE proceedings Int. Soc. Opt. Eng. vol. 5322 p.64-74 (2004)

129. J.K. Dreyer, P.M. Hansen, and L.B. Oddershede Optical probing of specific and non-specific interacions with nano-meter resolution SPIE proceedings vol. 5514 p.402-409 august (2004)

130. K. Berg-Sørensen, E.J.G. Peterman, L.B. Oddershede, M van Dijk, C.F. Schmidt, H. Flyvbjerg Parasitic filtering in optical tweezers detection systems SPIE proceedings vol. 5514 p. 419-427, august (2004)

Popular/ Outreach

131. L. Oddershede, R. Jacobsen, K. Lefmann, and N. Thoft PHOTON - an optical game KVANT (J. Dan. Phys. Soc.), vol. 4, p. 9-18 (1994)

132. Lene Oddershede Singularities in a glass of water Gamma no. 114, p. 6-16 (1999)

133. Lene Oddershede Optisk pincet mlinger af enkelt proteins bevgelser i bakterie membranen KVANT vol. 1, p. 3-8 (2002)

134. Lene Oddershede Optical probing of living organisms DOPS-NYT vol.4, p. 5-15 (2003)

135. L. Oddershede, R. Chancey, F. E. Harris og J. R. Sabin Fragmentering af fullerener KVANT vol. 2, p.3-7 (2003)

136. Georg M. Bruun, Birthe B. Kragelund, og Lene Oddershede Universitetsstuderendes tilgang til eksperimentelt udstyr - knslige og faglige aspekter Center for Naturfagenes Didaktik, November 2003

137. L. Oddershede (medlem af arbejdsgruppe nedsat af undervisningsministeriet) Fremtidens naturfaglige uddannelser - Naturfag for alle - vision og oplæg til strategi Uddannelsesstyrelsens temahfteserie

vol. 7, p. 1-103 (2003)

138. L. Oddershede Chapter on optical tweezers Spectrum (for gymnasium), by C. Claussen, Gylden- dal 2004

139. H. Flyvbjerg, K. Berg-Sørensen og L. Oddershede Brownske bevgelser, fra Einstein til optiske pincetter KVANT vol. 2, p. 6-9 (2005)

140. P.M. Hansen, T.W. Madsen, og L. Oddershede Vild med lys KVANT vol. 4, p. 14-17 (2005)

141. M.H. Jensen og L. Oddershede BioNET - nyt dansk center for moderne biologisk fysik Villum Kann Rasmussen Fondens rsskrift (2005)

142. L. Oddershede Optisk manipulation af nanopartikler GAMMA, vol. 140, p. 11-17 (2005)

143. K. Berg-Sørensen, M. Fischer, P.M. Hansen, L. Oddershede Cellers nano-mekanik KVANT (2007).

Manuscripts under review, available upon request

144. Physical properties and actin organization in embryonic stem cells depend on differentiation stage.   K.G. Hvid, Y. F. Barooji, I. I. Petitjean, J. M. Brickman, L.B. Oddershede, P. M. Bendix. BioRxiv (2020).

145. Systematically extracting, quantifying and comparing dynamical and biomechanical properties of living matter. C. Selhuber-Unkel, M. Weiss, S. Scott, Y. F. Barooji, A. Sabri, J. T. Erler, R. Metzler, L. B. Oddershede. Under review in Nature Reviews Physics.

146. Basement membrane stiffness determines metastases formation. R. Reuten et al. Under reveiw in Nature Methods.

147. Quantification of visco-elastic properties of a matrigel for organoid development as a function of polymer concentration. M. Borries, Y. F. Barooji, S. Yennek, A. Grapin-Botton, K. Berg- Sørensen, L. B. Oddershede. Under review in Frontiers.

148. Impact of Collagen Structure and Stiffness on Cancer Cell Invasion. N.S. Rossen et al. Under review in PNAS.

 



 

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