Forskning ved Københavns Universitet - Københavns Universitet

Forside
Morten Hanefeld Dziegiel

Morten Hanefeld Dziegiel

Klinisk lektor

  • Institut for Klinisk Medicin

    Rigshospitalet - Diagnostisk Center, Blegdamsvej 9, 2100 København Ø

    Danmark

    Telefon: +45 35 45 27 16

Interesseområder

Our special focus is feto-maternal immuno-hematology.

We are interested in mechanisms of immune destruction, immunoglobulins, effects of immunoglobulins, 'designer antibodies' with anti-hemolytic effect against anti-D antibodies, and recombinant therapeutic antibodies against Plasmodium falciparum.

A second interest is genetics of blood groups, and antenatal fetal blood group determination based on cell free fetal DNA in maternal plasma using PCR and Next Generation Sequencing (NGS).

A spin-off from our production of more than 15,000 individual analyses of fetal RHD in RHD negative pregnant women was the finding that a simple quantification of cell free fetal DNA in maternal plasma predicts preterm delivery as well as preeclampsia.

We are now pursuing the identification of supplementary markers for preeclampsia.

My laboratory has investigated feto-maternal hemorrhage from fetus to mother by flow cytometry.

 

 

 

 

 

Udvalgte publikationer

  1. Udgivet

    FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS

    Liu, Y., Carlsson, R., Comabella, M., Wang, J., Kosicki, M. K., Carrion, B., Hasan, M., Wu, X., Montalban, X., Dziegiel, M. H., Sellebjerg, F., Sørensen, P. S., Helin, K. & Navikas, S. 16 feb. 2014 I : Nature Medicine.

    Publikation: Forskning - peer reviewTidsskriftartikel

  2. Udgivet

    Maternofetal transplacental transport of recombinant IgG antibodies lacking effector functions

    Mathiesen, L., Nielsen, L. K., Andersen, J. T., Grevys, A., Sandlie, I., Michaelsen, T. E., Hedegaard, M., Knudsen, L. E. & Dziegiel, M. H. 10 jul. 2013 I : Blood. 122, 7, s. 1174-1181

    Publikation: Forskning - peer reviewTidsskriftartikel

  3. Udgivet

    Report of the first nationally implemented clinical routine screening for fetal RHD in D- pregnant women to ascertain the requirement for antenatal RhD prophylaxis

    Clausen, F. B., Christiansen, M., Steffensen, R. N., Jørgensen, S., Nielsen, C., Jakobsen, M. A., Madsen, R. D., Jensen, K., Krog, G. R., Rieneck, K., Sprogøe, U., Homburg, K. M., Grunnet, N. & Dziegiel, M. H. 2012 I : Transfusion. 52, 4, s. 752-758

    Publikation: Forskning - peer reviewTidsskriftartikel

  4. Udgivet

    Next-generation sequencing: proof of concept for antenatal prediction of the fetal Kell blood group phenotype from cell-free fetal DNA in maternal plasma

    Rieneck, K., Bak, M., Jønson, L., Clausen, F. B., Krog, G. R., Tommerup, N., Nielsen, L. K., Hedegaard, M. & Dziegiel, M. H. nov. 2013 I : Transfusion. 53, 11 Suppl 2, s. 2892-2898 7 s.

    Publikation: Forskning - peer reviewTidsskriftartikel

  5. Udgivet

    Identifying mild and severe preeclampsia in asymptomatic pregnant women by levels of cell-free fetal DNA

    Jakobsen, T. R., Clausen, F. B., Rode, L., Dziegiel, M. H. & Tabor, A. 16 jan. 2013 I : Transfusion.

    Publikation: Forskning - peer reviewTidsskriftartikel

  6. Udgivet

    High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery

    Jakobsen, T. R., Clausen, F. B., Rode, L., Dziegiel, M. H. & Tabor, A. sep. 2012 I : Journal of Prenatal Diagnosis and Therapy. 32, 9, s. 840-5 6 s.

    Publikation: Forskning - peer reviewTidsskriftartikel

  7. Udgivet

    Human recombinant antibodies against Plasmodium falciparum merozoite surface protein 3 cloned from peripheral blood leukocytes of individuals with immunity to malaria demonstrate antiparasitic properties

    Lundquist, R., Nielsen, L. K., Jafarshad, A., Soesoe, D., Christensen, L. H., Druilhe, P. & Dziegiel, M. H. jun. 2006 I : Infection and Immunity. 74, 6, s. 3222-31 10 s.

    Publikation: Forskning - peer reviewTidsskriftartikel

  8. Udgivet

    Recombinant anti-Plasmodium falciparum antibodies

    Dziegiel, M., Nielsen, L. K., Lundquist, R. & Druilhe, P. 2010 JP4475949 (B2)

    Publikation: ForskningPatent

  9. Udgivet

    Red blood cell antibodies in pregnancy and their clinical consequences: synergistic effects of multiple specificities

    Nordvall, M., Dziegiel, M. H., Hegaard, H. K., Bidstrup, M., Jonsbo, F., Christensen, B. & Hedegaard, M. okt. 2009 I : Transfusion. 49, 10, s. 2070-5 6 s.

    Publikation: Forskning - peer reviewTidsskriftartikel

  10. Udgivet

    Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle

    Borre, M. B., Dziegiel, M., Høgh, B., Pedersen, E., Rieneck, K., Riley, E., Meis, J. F., Aikawa, M., Nakamura, K. & Harada, M. 1991 I : Molecular and Biochemical Parasitology. 49, 1, s. 119-31 12 s.

    Publikation: Forskning - peer reviewTidsskriftartikel

  11. Udgivet

    Human anti-rhesus D IgG1 antibody produced in transgenic plants.

    Bouquin, T., Thomsen, M., Nielsen, L. K., Green, T. H., Mundy, J. & Dziegiel, M. H. 2002 I : Transgenic Research. 11, 2, s. 115-22 7 s.

    Publikation: Forskning - peer reviewTidsskriftartikel

ID: 984777