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β Cell Dysfunction in Type 2 Diabetes: Drained of Energy?

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Type 2 diabetes is a progressive disorder, but exactly how the progression occurs remains unknown. In this issue of Cell Metabolism, Zhang et al. (2019) present evidence that diabetes, via hyperglycemia, leads to aberrant insertion of a mitochondrial ion channel in the plasma membrane, rendering it leaky to key intracellular signaling molecules with resultant suppression of insulin secretion.

OriginalsprogEngelsk
TidsskriftCell Metabolism
Vol/bind29
Udgave nummer1
Sider (fra-til)1-2
Antal sider2
ISSN1550-4131
DOI
StatusUdgivet - 2019
Eksternt udgivetJa

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