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21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I

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21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I. / Berglund, A.; Cleemann, L.; Oftedal, B. E.; Holm, K.; Husebye, E. S.; Gravholt, C. H.

I: Clinical and Experimental Immunology, Bind 195, Nr. 3, 2019, s. 364-368.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Berglund, A, Cleemann, L, Oftedal, BE, Holm, K, Husebye, ES & Gravholt, CH 2019, '21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I', Clinical and Experimental Immunology, bind 195, nr. 3, s. 364-368. https://doi.org/10.1111/cei.13231

APA

Berglund, A., Cleemann, L., Oftedal, B. E., Holm, K., Husebye, E. S., & Gravholt, C. H. (2019). 21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I. Clinical and Experimental Immunology, 195(3), 364-368. https://doi.org/10.1111/cei.13231

Vancouver

Berglund A, Cleemann L, Oftedal BE, Holm K, Husebye ES, Gravholt CH. 21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I. Clinical and Experimental Immunology. 2019;195(3):364-368. https://doi.org/10.1111/cei.13231

Author

Berglund, A. ; Cleemann, L. ; Oftedal, B. E. ; Holm, K. ; Husebye, E. S. ; Gravholt, C. H. / 21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I. I: Clinical and Experimental Immunology. 2019 ; Bind 195, Nr. 3. s. 364-368.

Bibtex

@article{3e6a5ed0751f4b2199dcdb0bb9b6e2db,
title = "21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I",
abstract = "Turner syndrome (TS) is associated with an increased frequency of autoimmunity. Frequently observed autoimmune diseases in TS are also seen in the autoimmune polyendocrine syndrome type I (APS I), of which Addison disease is a key component. An overlapping antibody profile between TS and APS I could be considered. The aim of this work was to study women with TS regarding 21-hydroxylase (21-OH) antibodies and interferon omega (IFN-ω) antibodies, a highly specific marker for APS I, to determine if there are immunological overlaps between TS and APS I. Blood samples from 141 TS were assayed for 21-OH antibodies and IFN-ω antibodies using in-vitro-transcribed and translated autoantigen. Indices with a cut-off point of 57 and 200 for 21-OH antibody and IFN-ω antibody were used as reference. The median age of TS was 31·6 years (range = 11·2–62·2). Positive indices of 21-OH antibodies were present in six TS (4{\%}), with a mean of 144·8 (range = 60–535). None had apparent adrenal insufficiency. There was no age difference comparing 21-OH antibody-positive TS (median age = 33·9 years, range = 17·7–44·7) and 21-OH antibody-negative TS (median age = 31·6 years, range = 11·2–62·2) (P = 0·8). No TS was positive for IFN-ω antibodies (mean = 42·4, range = –435–191). No overlapping autoimmune profile between TS and APS I was found. Autoimmunity against 21-OH among TS patients was more prevalent than previously identified, suggesting an increased risk of adrenal failure in TS. However, whether adrenal impairment will develop remains unknown.",
keywords = "adrenal insufficiency, autoimmune polyendocrine syndrome type, Turner syndrome",
author = "A. Berglund and L. Cleemann and Oftedal, {B. E.} and K. Holm and Husebye, {E. S.} and Gravholt, {C. H.}",
year = "2019",
doi = "10.1111/cei.13231",
language = "English",
volume = "195",
pages = "364--368",
journal = "Clinical and Experimental Immunology",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - 21-hydroxylase autoantibodies are more prevalent in Turner syndrome but without an association to the autoimmune polyendocrine syndrome type I

AU - Berglund, A.

AU - Cleemann, L.

AU - Oftedal, B. E.

AU - Holm, K.

AU - Husebye, E. S.

AU - Gravholt, C. H.

PY - 2019

Y1 - 2019

N2 - Turner syndrome (TS) is associated with an increased frequency of autoimmunity. Frequently observed autoimmune diseases in TS are also seen in the autoimmune polyendocrine syndrome type I (APS I), of which Addison disease is a key component. An overlapping antibody profile between TS and APS I could be considered. The aim of this work was to study women with TS regarding 21-hydroxylase (21-OH) antibodies and interferon omega (IFN-ω) antibodies, a highly specific marker for APS I, to determine if there are immunological overlaps between TS and APS I. Blood samples from 141 TS were assayed for 21-OH antibodies and IFN-ω antibodies using in-vitro-transcribed and translated autoantigen. Indices with a cut-off point of 57 and 200 for 21-OH antibody and IFN-ω antibody were used as reference. The median age of TS was 31·6 years (range = 11·2–62·2). Positive indices of 21-OH antibodies were present in six TS (4%), with a mean of 144·8 (range = 60–535). None had apparent adrenal insufficiency. There was no age difference comparing 21-OH antibody-positive TS (median age = 33·9 years, range = 17·7–44·7) and 21-OH antibody-negative TS (median age = 31·6 years, range = 11·2–62·2) (P = 0·8). No TS was positive for IFN-ω antibodies (mean = 42·4, range = –435–191). No overlapping autoimmune profile between TS and APS I was found. Autoimmunity against 21-OH among TS patients was more prevalent than previously identified, suggesting an increased risk of adrenal failure in TS. However, whether adrenal impairment will develop remains unknown.

AB - Turner syndrome (TS) is associated with an increased frequency of autoimmunity. Frequently observed autoimmune diseases in TS are also seen in the autoimmune polyendocrine syndrome type I (APS I), of which Addison disease is a key component. An overlapping antibody profile between TS and APS I could be considered. The aim of this work was to study women with TS regarding 21-hydroxylase (21-OH) antibodies and interferon omega (IFN-ω) antibodies, a highly specific marker for APS I, to determine if there are immunological overlaps between TS and APS I. Blood samples from 141 TS were assayed for 21-OH antibodies and IFN-ω antibodies using in-vitro-transcribed and translated autoantigen. Indices with a cut-off point of 57 and 200 for 21-OH antibody and IFN-ω antibody were used as reference. The median age of TS was 31·6 years (range = 11·2–62·2). Positive indices of 21-OH antibodies were present in six TS (4%), with a mean of 144·8 (range = 60–535). None had apparent adrenal insufficiency. There was no age difference comparing 21-OH antibody-positive TS (median age = 33·9 years, range = 17·7–44·7) and 21-OH antibody-negative TS (median age = 31·6 years, range = 11·2–62·2) (P = 0·8). No TS was positive for IFN-ω antibodies (mean = 42·4, range = –435–191). No overlapping autoimmune profile between TS and APS I was found. Autoimmunity against 21-OH among TS patients was more prevalent than previously identified, suggesting an increased risk of adrenal failure in TS. However, whether adrenal impairment will develop remains unknown.

KW - adrenal insufficiency

KW - autoimmune polyendocrine syndrome type

KW - Turner syndrome

U2 - 10.1111/cei.13231

DO - 10.1111/cei.13231

M3 - Journal article

C2 - 30372540

AN - SCOPUS:85056451331

VL - 195

SP - 364

EP - 368

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 3

ER -

ID: 235785648