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5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern. / Bondesen, S; Nielsen, O H; Jacobsen, O; Rasmussen, S N; Hansen, S H; Halskov, S; Binder, V; Hvidberg, E F.

I: Scandinavian Journal of Gastroenterology, Bind 19, Nr. 5, 1984, s. 677-82.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bondesen, S, Nielsen, OH, Jacobsen, O, Rasmussen, SN, Hansen, SH, Halskov, S, Binder, V & Hvidberg, EF 1984, '5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern', Scandinavian Journal of Gastroenterology, bind 19, nr. 5, s. 677-82.

APA

Bondesen, S., Nielsen, O. H., Jacobsen, O., Rasmussen, S. N., Hansen, S. H., Halskov, S., Binder, V., & Hvidberg, E. F. (1984). 5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern. Scandinavian Journal of Gastroenterology, 19(5), 677-82.

Vancouver

Bondesen S, Nielsen OH, Jacobsen O, Rasmussen SN, Hansen SH, Halskov S o.a. 5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern. Scandinavian Journal of Gastroenterology. 1984;19(5):677-82.

Author

Bondesen, S ; Nielsen, O H ; Jacobsen, O ; Rasmussen, S N ; Hansen, S H ; Halskov, S ; Binder, V ; Hvidberg, E F. / 5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern. I: Scandinavian Journal of Gastroenterology. 1984 ; Bind 19, Nr. 5. s. 677-82.

Bibtex

@article{6d17ecfe6b89424594092d903a56f4cb,
title = "5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern",
abstract = "Enemas containing 1000 mg 5-ASA were administered to patients with active distal colitis in three separate studies: as a single dose in a neutral solution (pH 7.4); as a single dose in a slightly acidic, buffered suspension (pH 4.8); and as multiple doses once a day for 10 days with the acidic enema. 5-ASA was relatively rapidly absorbed from the neutral solution, resulting in plasma concentrations of 5-ASA sometimes two to three times higher than those found after peroral salazosulphapyridine (SASP) treatment. In contrast, absorption from the acidic enema was reduced and/or prolonged, giving plasma concentrations similar to those found during oral SASP treatment. After repeated doses of the acidic enema, plasma concentrations after an enema resembled those seen after the single dose. Urinary excretion was significantly lower, suggesting a reduced fraction of absorption at steady-state conditions. No side effects were observed, and no local irritation was reported. An acidic buffer suspension with 5-ASA seems to be safe for use as enema and deserves further clinical testing for treatment of distal ulcerative colitis.",
keywords = "Adolescent, Adult, Aminosalicylic Acids/administration & dosage, Clinical Trials as Topic, Colitis, Ulcerative/drug therapy, Enema, Female, Humans, Hydrogen-Ion Concentration, Kinetics, Male, Mesalamine, Middle Aged",
author = "S Bondesen and Nielsen, {O H} and O Jacobsen and Rasmussen, {S N} and Hansen, {S H} and S Halskov and V Binder and Hvidberg, {E F}",
year = "1984",
language = "English",
volume = "19",
pages = "677--82",
journal = "Scandinavian Journal of Gastroenterology. Supplement",
issn = "0085-5928",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - 5-Aminosalicylic acid enemas in patients with active ulcerative colitis. Influence of acidity on the kinetic pattern

AU - Bondesen, S

AU - Nielsen, O H

AU - Jacobsen, O

AU - Rasmussen, S N

AU - Hansen, S H

AU - Halskov, S

AU - Binder, V

AU - Hvidberg, E F

PY - 1984

Y1 - 1984

N2 - Enemas containing 1000 mg 5-ASA were administered to patients with active distal colitis in three separate studies: as a single dose in a neutral solution (pH 7.4); as a single dose in a slightly acidic, buffered suspension (pH 4.8); and as multiple doses once a day for 10 days with the acidic enema. 5-ASA was relatively rapidly absorbed from the neutral solution, resulting in plasma concentrations of 5-ASA sometimes two to three times higher than those found after peroral salazosulphapyridine (SASP) treatment. In contrast, absorption from the acidic enema was reduced and/or prolonged, giving plasma concentrations similar to those found during oral SASP treatment. After repeated doses of the acidic enema, plasma concentrations after an enema resembled those seen after the single dose. Urinary excretion was significantly lower, suggesting a reduced fraction of absorption at steady-state conditions. No side effects were observed, and no local irritation was reported. An acidic buffer suspension with 5-ASA seems to be safe for use as enema and deserves further clinical testing for treatment of distal ulcerative colitis.

AB - Enemas containing 1000 mg 5-ASA were administered to patients with active distal colitis in three separate studies: as a single dose in a neutral solution (pH 7.4); as a single dose in a slightly acidic, buffered suspension (pH 4.8); and as multiple doses once a day for 10 days with the acidic enema. 5-ASA was relatively rapidly absorbed from the neutral solution, resulting in plasma concentrations of 5-ASA sometimes two to three times higher than those found after peroral salazosulphapyridine (SASP) treatment. In contrast, absorption from the acidic enema was reduced and/or prolonged, giving plasma concentrations similar to those found during oral SASP treatment. After repeated doses of the acidic enema, plasma concentrations after an enema resembled those seen after the single dose. Urinary excretion was significantly lower, suggesting a reduced fraction of absorption at steady-state conditions. No side effects were observed, and no local irritation was reported. An acidic buffer suspension with 5-ASA seems to be safe for use as enema and deserves further clinical testing for treatment of distal ulcerative colitis.

KW - Adolescent

KW - Adult

KW - Aminosalicylic Acids/administration & dosage

KW - Clinical Trials as Topic

KW - Colitis, Ulcerative/drug therapy

KW - Enema

KW - Female

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Kinetics

KW - Male

KW - Mesalamine

KW - Middle Aged

M3 - Journal article

C2 - 6382570

VL - 19

SP - 677

EP - 682

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

IS - 5

ER -

ID: 218748404