Forskning ved Københavns Universitet - Københavns Universitet


5'-AMP Activated Protein Kinase is Involved in the Regulation of Myocardial β-Oxidative Capacity in Mice

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  • Nis Ottesen Stride
  • Steen Larsen
  • Jonas Thue Treebak
  • Christina Neigaard Hansen
  • Martin Hey-Mogensen
  • Tobias Speerschneider
  • Thomas Jensen
  • Jacob Jeppesen
  • Jørgen Wojtaszewski
  • Erik Richter
  • Køber, Lars Valeur
  • Flemming Dela
5'-adenosine monophosphate-activated protein kinase (AMPK) is considered central in regulation of energy status and substrate utilization within cells. In heart failure the energetic state is compromised and substrate metabolism is altered. We hypothesized that this could be linked to changes in AMPK activity and we therefore investigated mitochondrial oxidative phosphorylation capacity from the oxidation of long- and medium-chain fatty acids (LCFA and MCFA) in cardiomyocytes from young and old mice expressing a dominant negative AMPKα2 (AMPKα2-KD) construct and their wildtype (WT) littermates. We found a 35-45% (P 
TidsskriftFrontiers in Physiology
Sider (fra-til)33
StatusUdgivet - 2012

ID: 48506435