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9-Acridinylpeptides and 9-acridinyl-4-nitrophenylsulfonylpeptides. Synthesis, binding to DNA, and photoinduced DNA cleavage

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The preparation of 6-(9-acridinylamino)hexanoic acid DHBT ester and N alpha-Fmoc-N epsilon-(4-nitrophenylsulfonyl)-L-lysine DHBT ester and their application in solid phase peptide synthesis are described. The 9-acridinylamino ligand was shown to confer high DNA affinity, probably by intercalation, to the resulting peptides. The 4-nitrophenylsulfamido ligand furthermore resulted in "photonuclease" activity of some of the modified peptides.

OriginalsprogEngelsk
TidsskriftInternational Journal of Peptide and Protein Research
Vol/bind32
Udgave nummer5
Sider (fra-til)331-43
Antal sider13
ISSN0367-8377
StatusUdgivet - nov. 1988

ID: 203631170