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A Biomarker Panel Increases the Diagnostic Performance for Epithelial Ovarian Cancer Type I and II in Young Women

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Pia Leandersson
  • Grigorios Kalapotharakos
  • Emir Henic
  • Henrik Borgfeldt
  • Max Petzold
  • Gunilla Høyer-Hansen
  • Christer Borgfeldt

BACKGROUND/AIM: To assess preoperative blood levels of a biomarker panel in relation to the new classification system of epithelial ovarian cancer (EOC) type I and II.

PATIENTS AND METHODS: Preoperative plasma levels of B7-family protein homolog 4 (B7-H4), intact and cleaved soluble urokinase plasminogen activator receptor (suPAR), human epididymis protein 4 (HE4) and cancer antigen 125 (CA125) were analyzed in 350 patients with adnexal lesions.

RESULTS: The levels of suPAR(II-III), HE4, CA125 were all higher in EOC II than in EOC I, borderline and benign ovarian tumors. B7-H4 was increased in EOC II compared with benign ovarian tumors. The combination of suPAR(II-III), HE4, CA125 and age in premenopausal women discriminates EOC and borderline tumors from benign tumors to higher accuracy compared to the Risk of Ovarian Malignancy Algorithm (p=0.007).

CONCLUSION: The biomarker panel suPAR(II-III), HE4, CA125 and age in premenopausal women improved discrimination of malignant and benign ovarian tumors. The plasma levels of B7-H4 were increased in patients with EOC II compared to those with benign ovarian tumors.

OriginalsprogEngelsk
TidsskriftAnticancer Research
Vol/bind36
Udgave nummer3
Sider (fra-til)957-65
Antal sider9
ISSN0250-7005
StatusUdgivet - mar. 2016
Eksternt udgivetJa

ID: 179358048