Forskning ved Københavns Universitet - Københavns Universitet


A chimeric fusion of the hASH1 and EZH2 promoters mediates high and specific reporter and suicide gene expression and cytotoxicity in small cell lung cancer cells

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Transcriptionally targeted gene therapy is a promising experimental modality for treatment of systemic malignancies such as small cell lung cancer (SCLC). We have identified the human achaete-scute homolog 1 (hASH1) and enhancer of zeste homolog 2 (EZH2) genes as highly upregulated in SCLC compared to a panel of representative normal tissues. Here, we evaluate the use of regulatory regions from the h
Udgivelsesdato: 2008/9
TidsskriftCancer Gene Therapy
Udgave nummer9
Sider (fra-til)563-575
Antal sider12
StatusUdgivet - 2008

ID: 14275489