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A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks

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Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.

OriginalsprogEngelsk
Artikelnummer1605820
TidsskriftMolecular & Cellular Oncology
Vol/bind6
Udgave nummer4
Antal sider3
ISSN2372-3556
DOI
StatusUdgivet - 2019

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