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A common variant within the HNF1B gene is associated with overall survival of multiple myeloma patients: results from the IMMEnSE consortium and meta-analysis

Publikation: Bidrag til tidsskriftTidsskriftartikel

  • Rafael Ríos-Tamayo
  • Carmen Belén Lupiañez
  • Daniele Campa
  • Thomas Hielscher
  • Niels Weinhold
  • Joaquin Martinez-Lopez
  • Andrés Jerez
  • Stefano Landi
  • Krzysztof Jamroziak
  • Charles Dumontet
  • Marzena Wątek
  • Fabienne Lesueur
  • Rui Manuel Reis
  • Herlander Marques
  • Artur Jurczyszyn
  • Ulla Vogel
  • Gabriele Buda
  • Ramón García-Sanz
  • Enrico Orciuolo
  • Mario Petrini
  • Federica Gemignani
  • Asta Försti
  • Hartmut Goldschmidt
  • Kari Hemminki
  • Federico Canzian
  • Manuel Jurado
  • Juan Sainz

Diabetogenic single nucleotide polymorphisms (SNPs) have recently been associated with multiple myeloma (MM) risk but their impact on overall survival (OS) of MM patients has not been analysed yet. In order to investigate the impact of 58 GWAS-identified variants for type 2 diabetes (T2D) on OS of patients with MM, we analysed genotyping data of 936 MM patients collected by the International Multiple Myeloma rESEarch (IMMENSE) consortium and an independent set of 700 MM patients recruited by the University Clinic of Heidelberg. A meta-analysis of the cox regression results of the two sets showed that rs7501939 located in the HNF1B gene negatively impacted OS (HRRec= 1.44, 95% CI = 1.18-1.76, P = 0.0001). The meta-analysis also showed a noteworthy gender-specific association of the SLC30A8rs13266634 SNP with OS. The presence of each additional copy of the minor allele at rs13266634 was associated with poor OS in men whereas no association was seen in women (HRMen-Add = 1.32, 95% CI 1.13-1.54, P = 0.0003). In conclusion, these data suggest that the HNF1Brs7501939 SNP confers poor OS in patients with MM and that a SNP in SLC30A8 affect OS in men.

OriginalsprogEngelsk
TidsskriftOncoTarget
Vol/bind7
Udgave nummer37
Sider (fra-til)59029-59048
Antal sider20
ISSN1949-2553
DOI
StatusUdgivet - 2016

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