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A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps

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A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps. / Håkansson, Kåre; Thomsen, Simon Francis; Konge, Lars; Mortensen, Jann; Backer, Vibeke; von Buchwald, Christian.

I: American Journal of Rhinology & Allergy, Bind 28, Nr. 5, 10.09.2014, s. 383-387.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Håkansson, K, Thomsen, SF, Konge, L, Mortensen, J, Backer, V & von Buchwald, C 2014, 'A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps', American Journal of Rhinology & Allergy, bind 28, nr. 5, s. 383-387. https://doi.org/10.2500/ajra.2014.28.4076

APA

Håkansson, K., Thomsen, S. F., Konge, L., Mortensen, J., Backer, V., & von Buchwald, C. (2014). A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps. American Journal of Rhinology & Allergy, 28(5), 383-387. https://doi.org/10.2500/ajra.2014.28.4076

Vancouver

Håkansson K, Thomsen SF, Konge L, Mortensen J, Backer V, von Buchwald C. A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps. American Journal of Rhinology & Allergy. 2014 sep 10;28(5):383-387. https://doi.org/10.2500/ajra.2014.28.4076

Author

Håkansson, Kåre ; Thomsen, Simon Francis ; Konge, Lars ; Mortensen, Jann ; Backer, Vibeke ; von Buchwald, Christian. / A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps. I: American Journal of Rhinology & Allergy. 2014 ; Bind 28, Nr. 5. s. 383-387.

Bibtex

@article{664253200bca4060be35ad4dfe885439,
title = "A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps",
abstract = "BACKGROUND: Chronic rhinosinusitis (CRS) is a common health problem that is subclassified as CRS with nasal polyps (CRSwNPs) or CRS without NPs (CRSsNP). In accordance with the united airways concept, CRSwNPs frequently coexists with asthma but to date, this association remains unexplained and its strength is uncertain. Here, we aimed to examine the association between CRSwNPs and asthma in collaboration between the neighboring specialities: otorhinolaryngology and respiratory medicine.METHODS: A prospective clinical study was performed comprising 40 CRS patients scheduled for functional endoscopic sinus surgery and 21 control persons. We performed nasal endoscopy, peak expiratory flow, spirometry, and bronchodilation tests. In selected cases, additional pulmonary tests were performed. Atopy was assessed by skin-prick test or by measuring specific IgE in serum.RESULTS: Asthma was diagnosed in 26 patients with CRSwNPs (65%; odds ratio = 5.9 [1.79, 19.65]; p = 0.003), and 5 control persons (24%). Twenty-five percent of the CRSwNP patients had undiagnosed asthma. Atopy was not significantly associated with CRSwNPs (p = 0.39) or with coexisting asthma within the CRSwNP group (p = 0.50).CONCLUSION: Compared with previous studies, we found a very high prevalence of asthma and, frequently, asthma was undiagnosed. Furthermore, CRSwNPs was associated with chronic bronchitis and, in those with asthma, lower airway obstruction. These results call for a closer collaboration between otorhinolaryngology and respiratory medicine in relation to patients with CRSwNPs, in research as well as in clinical practice.",
author = "K{\aa}re H{\aa}kansson and Thomsen, {Simon Francis} and Lars Konge and Jann Mortensen and Vibeke Backer and {von Buchwald}, Christian",
year = "2014",
month = sep,
day = "10",
doi = "10.2500/ajra.2014.28.4076",
language = "English",
volume = "28",
pages = "383--387",
journal = "American Journal of Rhinology & Allergy",
issn = "1945-8924",
publisher = "OceanSide Publications, Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - A comparative and descriptive study of asthma in chronic rhinosinusitis with nasal polyps

AU - Håkansson, Kåre

AU - Thomsen, Simon Francis

AU - Konge, Lars

AU - Mortensen, Jann

AU - Backer, Vibeke

AU - von Buchwald, Christian

PY - 2014/9/10

Y1 - 2014/9/10

N2 - BACKGROUND: Chronic rhinosinusitis (CRS) is a common health problem that is subclassified as CRS with nasal polyps (CRSwNPs) or CRS without NPs (CRSsNP). In accordance with the united airways concept, CRSwNPs frequently coexists with asthma but to date, this association remains unexplained and its strength is uncertain. Here, we aimed to examine the association between CRSwNPs and asthma in collaboration between the neighboring specialities: otorhinolaryngology and respiratory medicine.METHODS: A prospective clinical study was performed comprising 40 CRS patients scheduled for functional endoscopic sinus surgery and 21 control persons. We performed nasal endoscopy, peak expiratory flow, spirometry, and bronchodilation tests. In selected cases, additional pulmonary tests were performed. Atopy was assessed by skin-prick test or by measuring specific IgE in serum.RESULTS: Asthma was diagnosed in 26 patients with CRSwNPs (65%; odds ratio = 5.9 [1.79, 19.65]; p = 0.003), and 5 control persons (24%). Twenty-five percent of the CRSwNP patients had undiagnosed asthma. Atopy was not significantly associated with CRSwNPs (p = 0.39) or with coexisting asthma within the CRSwNP group (p = 0.50).CONCLUSION: Compared with previous studies, we found a very high prevalence of asthma and, frequently, asthma was undiagnosed. Furthermore, CRSwNPs was associated with chronic bronchitis and, in those with asthma, lower airway obstruction. These results call for a closer collaboration between otorhinolaryngology and respiratory medicine in relation to patients with CRSwNPs, in research as well as in clinical practice.

AB - BACKGROUND: Chronic rhinosinusitis (CRS) is a common health problem that is subclassified as CRS with nasal polyps (CRSwNPs) or CRS without NPs (CRSsNP). In accordance with the united airways concept, CRSwNPs frequently coexists with asthma but to date, this association remains unexplained and its strength is uncertain. Here, we aimed to examine the association between CRSwNPs and asthma in collaboration between the neighboring specialities: otorhinolaryngology and respiratory medicine.METHODS: A prospective clinical study was performed comprising 40 CRS patients scheduled for functional endoscopic sinus surgery and 21 control persons. We performed nasal endoscopy, peak expiratory flow, spirometry, and bronchodilation tests. In selected cases, additional pulmonary tests were performed. Atopy was assessed by skin-prick test or by measuring specific IgE in serum.RESULTS: Asthma was diagnosed in 26 patients with CRSwNPs (65%; odds ratio = 5.9 [1.79, 19.65]; p = 0.003), and 5 control persons (24%). Twenty-five percent of the CRSwNP patients had undiagnosed asthma. Atopy was not significantly associated with CRSwNPs (p = 0.39) or with coexisting asthma within the CRSwNP group (p = 0.50).CONCLUSION: Compared with previous studies, we found a very high prevalence of asthma and, frequently, asthma was undiagnosed. Furthermore, CRSwNPs was associated with chronic bronchitis and, in those with asthma, lower airway obstruction. These results call for a closer collaboration between otorhinolaryngology and respiratory medicine in relation to patients with CRSwNPs, in research as well as in clinical practice.

U2 - 10.2500/ajra.2014.28.4076

DO - 10.2500/ajra.2014.28.4076

M3 - Journal article

C2 - 25198023

VL - 28

SP - 383

EP - 387

JO - American Journal of Rhinology & Allergy

JF - American Journal of Rhinology & Allergy

SN - 1945-8924

IS - 5

ER -

ID: 137745032