Forskning ved Københavns Universitet - Københavns Universitet

Forside

A comparative study of different albendazole and mebendazole regimens for the treatment of intestinal infections in school children of usigu division, Western Kenya

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

A comparative study of different albendazole and mebendazole regimens for the treatment of intestinal infections in school children of usigu division, Western Kenya. / Muchiri, E. M.; Thiong'o, F. W.; Magnussen, P.; Ouma, J. H.

I: Journal of Parasitology, Bind 87, Nr. 2, 01.01.2001, s. 413-418.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Muchiri, EM, Thiong'o, FW, Magnussen, P & Ouma, JH 2001, 'A comparative study of different albendazole and mebendazole regimens for the treatment of intestinal infections in school children of usigu division, Western Kenya', Journal of Parasitology, bind 87, nr. 2, s. 413-418. https://doi.org/10.1645/0022-3395(2001)087[0413:ACSODA]2.0.CO;2

APA

Muchiri, E. M., Thiong'o, F. W., Magnussen, P., & Ouma, J. H. (2001). A comparative study of different albendazole and mebendazole regimens for the treatment of intestinal infections in school children of usigu division, Western Kenya. Journal of Parasitology, 87(2), 413-418. https://doi.org/10.1645/0022-3395(2001)087[0413:ACSODA]2.0.CO;2

Vancouver

Muchiri EM, Thiong'o FW, Magnussen P, Ouma JH. A comparative study of different albendazole and mebendazole regimens for the treatment of intestinal infections in school children of usigu division, Western Kenya. Journal of Parasitology. 2001 jan 1;87(2):413-418. https://doi.org/10.1645/0022-3395(2001)087[0413:ACSODA]2.0.CO;2

Author

Muchiri, E. M. ; Thiong'o, F. W. ; Magnussen, P. ; Ouma, J. H. / A comparative study of different albendazole and mebendazole regimens for the treatment of intestinal infections in school children of usigu division, Western Kenya. I: Journal of Parasitology. 2001 ; Bind 87, Nr. 2. s. 413-418.

Bibtex

@article{a4427fca7a8f4680a57f85b66c7cb6f3,
title = "A comparative study of different albendazole and mebendazole regimens for the treatment of intestinal infections in school children of usigu division, Western Kenya",
abstract = "A clinical trial to compare the effectiveness of 4- and 6-mo repeated treatment with albendazole 600 mg (Zentel{\textregistered}, SmithKline Beecham) or mebendazole 600 mg (Vermox{\textregistered}, Janssen) on geohelminth infections was carried out on children in 6 primary schools; the study included 1,186 children, ages 4 to 19 yr. Kato-Katz examination was performed on stool samples before and after treatment. Overall, albendazole produced better cure rates and egg reduction rates for geohelminths. The cure rates for albendazole were 92.4% for hookworm infection, 83.5% for Ascaris lumbricoides, and 67.8% for Trichuris trichiura. Mebendazole given either 2 or 3 times in a year had cure rates of 50 and 55.0% (respectively) for hookworm, 79.6 and 97.5% for A. lumbricoides, and 60.6 and 68.3% for T. trichiura infection. The geometric mean intensity of hookworm eggs per gram (epg) of stool decreased by 96.7% after albendazole treatment compared with 66.3 and 85.1%, respectively, for 2 or 3 doses of mebendazole (P < 0.05) over the same period. Reductions in epg for A. lumbricoides and T. trichiura were comparable for both drugs. Our results indicate that treatment with albendazole at a 6-mo interval was more effective than mebendazole regimens and may be the best choice for use in the control of the 3 geohelminths.",
author = "Muchiri, {E. M.} and Thiong'o, {F. W.} and P. Magnussen and Ouma, {J. H.}",
year = "2001",
month = jan,
day = "1",
doi = "10.1645/0022-3395(2001)087[0413:ACSODA]2.0.CO;2",
language = "English",
volume = "87",
pages = "413--418",
journal = "Journal of Parasitology",
issn = "0022-3395",
publisher = "Allen Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - A comparative study of different albendazole and mebendazole regimens for the treatment of intestinal infections in school children of usigu division, Western Kenya

AU - Muchiri, E. M.

AU - Thiong'o, F. W.

AU - Magnussen, P.

AU - Ouma, J. H.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - A clinical trial to compare the effectiveness of 4- and 6-mo repeated treatment with albendazole 600 mg (Zentel®, SmithKline Beecham) or mebendazole 600 mg (Vermox®, Janssen) on geohelminth infections was carried out on children in 6 primary schools; the study included 1,186 children, ages 4 to 19 yr. Kato-Katz examination was performed on stool samples before and after treatment. Overall, albendazole produced better cure rates and egg reduction rates for geohelminths. The cure rates for albendazole were 92.4% for hookworm infection, 83.5% for Ascaris lumbricoides, and 67.8% for Trichuris trichiura. Mebendazole given either 2 or 3 times in a year had cure rates of 50 and 55.0% (respectively) for hookworm, 79.6 and 97.5% for A. lumbricoides, and 60.6 and 68.3% for T. trichiura infection. The geometric mean intensity of hookworm eggs per gram (epg) of stool decreased by 96.7% after albendazole treatment compared with 66.3 and 85.1%, respectively, for 2 or 3 doses of mebendazole (P < 0.05) over the same period. Reductions in epg for A. lumbricoides and T. trichiura were comparable for both drugs. Our results indicate that treatment with albendazole at a 6-mo interval was more effective than mebendazole regimens and may be the best choice for use in the control of the 3 geohelminths.

AB - A clinical trial to compare the effectiveness of 4- and 6-mo repeated treatment with albendazole 600 mg (Zentel®, SmithKline Beecham) or mebendazole 600 mg (Vermox®, Janssen) on geohelminth infections was carried out on children in 6 primary schools; the study included 1,186 children, ages 4 to 19 yr. Kato-Katz examination was performed on stool samples before and after treatment. Overall, albendazole produced better cure rates and egg reduction rates for geohelminths. The cure rates for albendazole were 92.4% for hookworm infection, 83.5% for Ascaris lumbricoides, and 67.8% for Trichuris trichiura. Mebendazole given either 2 or 3 times in a year had cure rates of 50 and 55.0% (respectively) for hookworm, 79.6 and 97.5% for A. lumbricoides, and 60.6 and 68.3% for T. trichiura infection. The geometric mean intensity of hookworm eggs per gram (epg) of stool decreased by 96.7% after albendazole treatment compared with 66.3 and 85.1%, respectively, for 2 or 3 doses of mebendazole (P < 0.05) over the same period. Reductions in epg for A. lumbricoides and T. trichiura were comparable for both drugs. Our results indicate that treatment with albendazole at a 6-mo interval was more effective than mebendazole regimens and may be the best choice for use in the control of the 3 geohelminths.

UR - http://www.scopus.com/inward/record.url?scp=0035045413&partnerID=8YFLogxK

U2 - 10.1645/0022-3395(2001)087[0413:ACSODA]2.0.CO;2

DO - 10.1645/0022-3395(2001)087[0413:ACSODA]2.0.CO;2

M3 - Journal article

C2 - 11318574

AN - SCOPUS:0035045413

VL - 87

SP - 413

EP - 418

JO - Journal of Parasitology

JF - Journal of Parasitology

SN - 0022-3395

IS - 2

ER -

ID: 224707811