Forskning ved Københavns Universitet - Københavns Universitet

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A draft sequence of the neandertal genome

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Richard E. Green
  • Johannes Krause
  • Adrian W. Briggs
  • Tomislav Maricic
  • Udo Stenzel
  • Martin Kircher
  • Nick Patterson
  • Heng Li
  • Weiwei Zhai
  • Markus Hsi Yang Fritz
  • Nancy F. Hansen
  • Eric Y. Durand
  • Anna-Sapfo Malaspinas
  • Jeffrey D. Jensen
  • Tomas Marques-Bonet
  • Can Alkan
  • Kay Prüfer
  • Matthias Meyer
  • Hernán A. Burbano
  • Jeffrey M. Good
  • Rigo Schultz
  • Ayinuer Aximu-Petri
  • Anne Butthof
  • Barbara Höber
  • Barbara Höffner
  • Madlen Siegemund
  • Antje Weihmann
  • Chad Nusbaum
  • Eric S. Lander
  • Carsten Russ
  • Nathaniel Novod
  • Jason Affourtit
  • Michael Egholm
  • Christine Verna
  • Pavao Rudan
  • Dejana Brajkovic
  • Željko Kucan
  • Ivan Gušic
  • Vladimir B. Doronichev
  • Liubov V. Golovanova
  • Carles Lalueza-Fox
  • Marco De La Rasilla
  • Javier Fortea
  • Antonio Rosas
  • Ralf W. Schmitz
  • Philip L. F. Johnson
  • Evan E. Eichler
  • Daniel Falush
  • Ewan Birney
  • James C. Mullikin
  • Montgomery Slatkin
  • Janet Kelso
  • Michael Lachmann
  • David Reich
  • Svante Pääbo

Neandertals, the closest evolutionary relatives of present-day humans, lived in large parts of Europe and western Asia before disappearing 30,000 years ago. We present a draft sequence of the Neandertal genome composed of more than 4 billion nucleotides from three individuals. Comparisons of the Neandertal genome to the genomes of five present-day humans from different parts of the world identify a number of genomic regions that may have been affected by positive selection in ancestral modern humans, including genes involved in metabolism and in cognitive and skeletal development. We show that Neandertals shared more genetic variants with present-day humans in Eurasia than with present-day humans in sub-Saharan Africa, suggesting that gene flow from Neandertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.

OriginalsprogEngelsk
TidsskriftScience
Vol/bind328
Udgave nummer5979
Sider (fra-til)710-722
Antal sider13
ISSN0036-8075
DOI
StatusUdgivet - 2010
Eksternt udgivetJa

ID: 222638257