Forskning ved Københavns Universitet - Københavns Universitet


A gamut of loops: meandering DNA

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  • Szabolcs Semsey
  • Konstantin Virnik
  • Sankar Adhya

Nucleoprotein complexes comprising short DNA loops (150 base pairs or less) are involved in a wide variety of DNA transactions (e.g. transcription regulation, replication and recombination) in both prokaryotes and eukaryotes, and also can be useful in designing nanostructures. In these higher-order nucleoprotein complexes, proteins bound to spatially separated sites on a DNA interact with each other by looping out the relatively stiff intervening DNA. Recent technological developments have enabled determination of DNA trajectories in a few DNA-loop-containing regulatory complexes. Results show that, in a given system, a specific DNA trajectory is preferred over others.

TidsskriftTrends in Biochemical Sciences
Udgave nummer6
Sider (fra-til)334-41
Antal sider8
StatusUdgivet - jun. 2005
Eksternt udgivetJa

ID: 163917787