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A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B

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  • Toshimasa Yamauchi
  • Kazuo Hara
  • Shiro Maeda
  • Kazuki Yasuda
  • Atsushi Takahashi
  • Momoko Horikoshi
  • Masahiro Nakamura
  • Hayato Fujita
  • Stephane Cauchi
  • Daniel P K Ng
  • Ronald C W Ma
  • Tatsuhiko Tsunoda
  • Michiaki Kubo
  • Hirotaka Watada
  • Hiroshi Maegawa
  • Miki Okada-Iwabu
  • Masato Iwabu
  • Nobuhiro Shojima
  • Hyoung Doo Shin
  • Gitte Andersen
  • Daniel R Witte
  • Torben Jørgensen
  • Torsten Lauritzen
  • Annelli Sandbæk
  • Torben Hansen
  • Toshihiko Ohshige
  • Shintaro Omori
  • Ikuo Saito
  • Kohei Kaku
  • Hiroshi Hirose
  • Wing-Yee So
  • Delphine Beury
  • Juliana C N Chan
  • Kyong Soo Park
  • E Shyong Tai
  • Chikako Ito
  • Yasushi Tanaka
  • Atsunori Kashiwagi
  • Ryuzo Kawamori
  • Masato Kasuga
  • Philippe Froguel
  • Naoyuki Kamatani
  • Yusuke Nakamura
  • Takashi Kadowaki
We conducted a genome-wide association study of type 2 diabetes (T2D) using 459,359 SNPs in a Japanese population with a three-stage study design (stage 1, 4,470 cases and 3,071 controls; stage 2, 2,886 cases and 3,087 controls; stage 3, 3,622 cases and 2,356 controls). We identified new associations in UBE2E2 on chromosome 3 and in C2CD4A-C2CD4B on chromosome 15 at genome-wide significant levels (rs7612463 in UBE2E2, combined P = 2.27 × 10¿¿; rs7172432 in C2CD4A-C2CD4B, combined P = 3.66 × 10¿¿). The association of these two loci with T2D was replicated in other east Asian populations. In the European populations, the C2CD4A-C2CD4B locus was significantly associated with T2D, and a combined analysis of all populations gave P = 8.78 × 10¿¹4, whereas the UBE2E2 locus did not show association to T2D. In conclusion, we identified two new loci at UBE2E2 and C2CD4A-C2CD4B associated with susceptibility to T2D.
OriginalsprogEngelsk
TidsskriftNature Genetics
Vol/bind42
Udgave nummer10
Sider (fra-til)864-8
Antal sider5
ISSN1061-4036
DOI
StatusUdgivet - 1 okt. 2010

ID: 33508665