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A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). / Enciso-Mora, Victor; Broderick, Peter; Ma, Yussanne; Jarrett, Ruth F; Hjalgrim, Henrik; Hemminki, Kari; Van Den Berg, Anke; Olver, Bianca; Lloyd, Amy; Dobbins, Sara E.; Lightfoot, Tracy; van Leeuwen, Flora E; Försti, Asta; Diepstra, Arjan; Broeks, Annegien; Vijayakrishnan, Jayaram; Shield, Lesley; Lake, Annette; Montgomery, Dorothy; Roman, Eve; Engert, Andreas; Von Strandmann, Elke Pogge; Reiners, Katrin S.; Nolte, Ilja M; Smedby, Karin E; Adami, Hans-Olov; Russell, Nicola S; Glimelius, Bengt; Hamilton-Dutoit, Stephen; De Bruin, Marieke; Ryder, Lars P.; Molin, Daniel G. M.; Sorensen, Karina Meden; Chang, Ellen T.; Taylor, A. Malcolm R.; Cooke, Rosie; Hofstra, Robert; Westers, Helga; Van Wezel, Tom; Van Eijk, Ronald; Ashworth, Alan; Rostgaard, Klaus; Melbye, Mads; Swerdlow, Anthony J; Houlston, Richard S.

I: Nature Genetics, Bind 42, Nr. 12, 12.2010, s. 1126-1130.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Enciso-Mora, V, Broderick, P, Ma, Y, Jarrett, RF, Hjalgrim, H, Hemminki, K, Van Den Berg, A, Olver, B, Lloyd, A, Dobbins, SE, Lightfoot, T, van Leeuwen, FE, Försti, A, Diepstra, A, Broeks, A, Vijayakrishnan, J, Shield, L, Lake, A, Montgomery, D, Roman, E, Engert, A, Von Strandmann, EP, Reiners, KS, Nolte, IM, Smedby, KE, Adami, H-O, Russell, NS, Glimelius, B, Hamilton-Dutoit, S, De Bruin, M, Ryder, LP, Molin, DGM, Sorensen, KM, Chang, ET, Taylor, AMR, Cooke, R, Hofstra, R, Westers, H, Van Wezel, T, Van Eijk, R, Ashworth, A, Rostgaard, K, Melbye, M, Swerdlow, AJ & Houlston, RS 2010, 'A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)', Nature Genetics, bind 42, nr. 12, s. 1126-1130. https://doi.org/10.1038/ng.696

APA

Enciso-Mora, V., Broderick, P., Ma, Y., Jarrett, R. F., Hjalgrim, H., Hemminki, K., ... Houlston, R. S. (2010). A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nature Genetics, 42(12), 1126-1130. https://doi.org/10.1038/ng.696

Vancouver

Enciso-Mora V, Broderick P, Ma Y, Jarrett RF, Hjalgrim H, Hemminki K o.a. A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nature Genetics. 2010 dec;42(12):1126-1130. https://doi.org/10.1038/ng.696

Author

Enciso-Mora, Victor ; Broderick, Peter ; Ma, Yussanne ; Jarrett, Ruth F ; Hjalgrim, Henrik ; Hemminki, Kari ; Van Den Berg, Anke ; Olver, Bianca ; Lloyd, Amy ; Dobbins, Sara E. ; Lightfoot, Tracy ; van Leeuwen, Flora E ; Försti, Asta ; Diepstra, Arjan ; Broeks, Annegien ; Vijayakrishnan, Jayaram ; Shield, Lesley ; Lake, Annette ; Montgomery, Dorothy ; Roman, Eve ; Engert, Andreas ; Von Strandmann, Elke Pogge ; Reiners, Katrin S. ; Nolte, Ilja M ; Smedby, Karin E ; Adami, Hans-Olov ; Russell, Nicola S ; Glimelius, Bengt ; Hamilton-Dutoit, Stephen ; De Bruin, Marieke ; Ryder, Lars P. ; Molin, Daniel G. M. ; Sorensen, Karina Meden ; Chang, Ellen T. ; Taylor, A. Malcolm R. ; Cooke, Rosie ; Hofstra, Robert ; Westers, Helga ; Van Wezel, Tom ; Van Eijk, Ronald ; Ashworth, Alan ; Rostgaard, Klaus ; Melbye, Mads ; Swerdlow, Anthony J ; Houlston, Richard S. / A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). I: Nature Genetics. 2010 ; Bind 42, Nr. 12. s. 1126-1130.

Bibtex

@article{16d23cdaf0084df6b4c9385cf13bcb19,
title = "A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)",
abstract = "To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10 -8), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10-13) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10-8). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10 -50). These data provide new insight into the pathogenesis of cHL.",
author = "Victor Enciso-Mora and Peter Broderick and Yussanne Ma and Jarrett, {Ruth F} and Henrik Hjalgrim and Kari Hemminki and {Van Den Berg}, Anke and Bianca Olver and Amy Lloyd and Dobbins, {Sara E.} and Tracy Lightfoot and {van Leeuwen}, {Flora E} and Asta F{\"o}rsti and Arjan Diepstra and Annegien Broeks and Jayaram Vijayakrishnan and Lesley Shield and Annette Lake and Dorothy Montgomery and Eve Roman and Andreas Engert and {Von Strandmann}, {Elke Pogge} and Reiners, {Katrin S.} and Nolte, {Ilja M} and Smedby, {Karin E} and Hans-Olov Adami and Russell, {Nicola S} and Bengt Glimelius and Stephen Hamilton-Dutoit and {De Bruin}, Marieke and Ryder, {Lars P.} and Molin, {Daniel G. M.} and Sorensen, {Karina Meden} and Chang, {Ellen T.} and Taylor, {A. Malcolm R.} and Rosie Cooke and Robert Hofstra and Helga Westers and {Van Wezel}, Tom and {Van Eijk}, Ronald and Alan Ashworth and Klaus Rostgaard and Mads Melbye and Swerdlow, {Anthony J} and Houlston, {Richard S}",
year = "2010",
month = "12",
doi = "10.1038/ng.696",
language = "English",
volume = "42",
pages = "1126--1130",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "12",

}

RIS

TY - JOUR

T1 - A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

AU - Enciso-Mora, Victor

AU - Broderick, Peter

AU - Ma, Yussanne

AU - Jarrett, Ruth F

AU - Hjalgrim, Henrik

AU - Hemminki, Kari

AU - Van Den Berg, Anke

AU - Olver, Bianca

AU - Lloyd, Amy

AU - Dobbins, Sara E.

AU - Lightfoot, Tracy

AU - van Leeuwen, Flora E

AU - Försti, Asta

AU - Diepstra, Arjan

AU - Broeks, Annegien

AU - Vijayakrishnan, Jayaram

AU - Shield, Lesley

AU - Lake, Annette

AU - Montgomery, Dorothy

AU - Roman, Eve

AU - Engert, Andreas

AU - Von Strandmann, Elke Pogge

AU - Reiners, Katrin S.

AU - Nolte, Ilja M

AU - Smedby, Karin E

AU - Adami, Hans-Olov

AU - Russell, Nicola S

AU - Glimelius, Bengt

AU - Hamilton-Dutoit, Stephen

AU - De Bruin, Marieke

AU - Ryder, Lars P.

AU - Molin, Daniel G. M.

AU - Sorensen, Karina Meden

AU - Chang, Ellen T.

AU - Taylor, A. Malcolm R.

AU - Cooke, Rosie

AU - Hofstra, Robert

AU - Westers, Helga

AU - Van Wezel, Tom

AU - Van Eijk, Ronald

AU - Ashworth, Alan

AU - Rostgaard, Klaus

AU - Melbye, Mads

AU - Swerdlow, Anthony J

AU - Houlston, Richard S

PY - 2010/12

Y1 - 2010/12

N2 - To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10 -8), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10-13) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10-8). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10 -50). These data provide new insight into the pathogenesis of cHL.

AB - To identify susceptibility loci for classical Hodgkin's lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 × 10 -8), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 × 10-13) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 × 10-8). Furthermore, we confirmed the role of the major histocompatibility complex in disease etiology by revealing a strong human leukocyte antigen (HLA) association (rs6903608, OR = 1.70, combined P = 2.84 × 10 -50). These data provide new insight into the pathogenesis of cHL.

UR - http://www.scopus.com/inward/record.url?scp=78649471895&partnerID=8YFLogxK

U2 - 10.1038/ng.696

DO - 10.1038/ng.696

M3 - Journal article

C2 - 21037568

AN - SCOPUS:78649471895

VL - 42

SP - 1126

EP - 1130

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 12

ER -

ID: 178220379