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A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity

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Standard

A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity. / Sonn, Katrin; Pankratova, Stanislava; Korshunova, Irina; Zharkovsky, Alexander; Bock, Elisabeth; Berezin, Vladimir; Kiryushko, Darya.

I: Journal of Neuroscience Research, Bind 88, Nr. 5, 2010, s. 1074-82.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Sonn, K, Pankratova, S, Korshunova, I, Zharkovsky, A, Bock, E, Berezin, V & Kiryushko, D 2010, 'A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity', Journal of Neuroscience Research, bind 88, nr. 5, s. 1074-82. https://doi.org/10.1002/jnr.22281

APA

Sonn, K., Pankratova, S., Korshunova, I., Zharkovsky, A., Bock, E., Berezin, V., & Kiryushko, D. (2010). A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity. Journal of Neuroscience Research, 88(5), 1074-82. https://doi.org/10.1002/jnr.22281

Vancouver

Sonn K, Pankratova S, Korshunova I, Zharkovsky A, Bock E, Berezin V o.a. A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity. Journal of Neuroscience Research. 2010;88(5):1074-82. https://doi.org/10.1002/jnr.22281

Author

Sonn, Katrin ; Pankratova, Stanislava ; Korshunova, Irina ; Zharkovsky, Alexander ; Bock, Elisabeth ; Berezin, Vladimir ; Kiryushko, Darya. / A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity. I: Journal of Neuroscience Research. 2010 ; Bind 88, Nr. 5. s. 1074-82.

Bibtex

@article{676fc040b1b811df825b000ea68e967b,
title = "A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity",
abstract = "Metallothioneins I and II (MTI/II) are metal-binding proteins overexpressed in response to brain injury. Recently, we have designed a peptide, termed EmtinB, which is modeled after the beta-domain of MT-II and mimics the biological effects of MTI/II in vitro. Here, we demonstrate the neuroprotective effect of EmtinB in the in vitro and in vivo models of kainic acid (KA)-induced neurotoxicity. We show that EmtinB passes the blood-brain barrier and is detectable in plasma for up to 24 hr. Treatment with EmtinB significantly attenuates seizures in C57BL/6J mice exposed to moderate (20 mg/kg) and high (30 mg/kg) KA doses and tends to decrease mortality induced by the high KA dose. Histopathological evaluation of hippocampal (CA3 and CA1) and cortical areas of mice treated with 20 mg/kg KA shows that EmtinB treatment reduces KA-induced neurodegeneration in the CA1 region. These findings establish EmtinB as a promising target for therapeutic development.",
author = "Katrin Sonn and Stanislava Pankratova and Irina Korshunova and Alexander Zharkovsky and Elisabeth Bock and Vladimir Berezin and Darya Kiryushko",
note = "Keywords: Animals; Blood-Brain Barrier; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Metallothionein; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Peptides; Rats; Rats, Wistar; Seizures",
year = "2010",
doi = "10.1002/jnr.22281",
language = "English",
volume = "88",
pages = "1074--82",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "JohnWiley & Sons, Inc.",
number = "5",

}

RIS

TY - JOUR

T1 - A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity

AU - Sonn, Katrin

AU - Pankratova, Stanislava

AU - Korshunova, Irina

AU - Zharkovsky, Alexander

AU - Bock, Elisabeth

AU - Berezin, Vladimir

AU - Kiryushko, Darya

N1 - Keywords: Animals; Blood-Brain Barrier; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe; Hippocampus; Kainic Acid; Male; Metallothionein; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Peptides; Rats; Rats, Wistar; Seizures

PY - 2010

Y1 - 2010

N2 - Metallothioneins I and II (MTI/II) are metal-binding proteins overexpressed in response to brain injury. Recently, we have designed a peptide, termed EmtinB, which is modeled after the beta-domain of MT-II and mimics the biological effects of MTI/II in vitro. Here, we demonstrate the neuroprotective effect of EmtinB in the in vitro and in vivo models of kainic acid (KA)-induced neurotoxicity. We show that EmtinB passes the blood-brain barrier and is detectable in plasma for up to 24 hr. Treatment with EmtinB significantly attenuates seizures in C57BL/6J mice exposed to moderate (20 mg/kg) and high (30 mg/kg) KA doses and tends to decrease mortality induced by the high KA dose. Histopathological evaluation of hippocampal (CA3 and CA1) and cortical areas of mice treated with 20 mg/kg KA shows that EmtinB treatment reduces KA-induced neurodegeneration in the CA1 region. These findings establish EmtinB as a promising target for therapeutic development.

AB - Metallothioneins I and II (MTI/II) are metal-binding proteins overexpressed in response to brain injury. Recently, we have designed a peptide, termed EmtinB, which is modeled after the beta-domain of MT-II and mimics the biological effects of MTI/II in vitro. Here, we demonstrate the neuroprotective effect of EmtinB in the in vitro and in vivo models of kainic acid (KA)-induced neurotoxicity. We show that EmtinB passes the blood-brain barrier and is detectable in plasma for up to 24 hr. Treatment with EmtinB significantly attenuates seizures in C57BL/6J mice exposed to moderate (20 mg/kg) and high (30 mg/kg) KA doses and tends to decrease mortality induced by the high KA dose. Histopathological evaluation of hippocampal (CA3 and CA1) and cortical areas of mice treated with 20 mg/kg KA shows that EmtinB treatment reduces KA-induced neurodegeneration in the CA1 region. These findings establish EmtinB as a promising target for therapeutic development.

U2 - 10.1002/jnr.22281

DO - 10.1002/jnr.22281

M3 - Journal article

C2 - 19937811

VL - 88

SP - 1074

EP - 1082

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 5

ER -

ID: 21602373