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A naturalistic glyceryl trinitrate infusion migraine model in the rat

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Glyceryl trinitrate (GTN) infusion is a reliable method to provoke migraine-like headaches in humans. Previous studies have simulated this human model in anaesthetized or in awake rodents using GTN doses 10,000 times higher than used in humans. The relevance of such toxicological doses to migraine is not certain. Anaesthesia and low blood pressure caused by high GTN doses both can affect the expression of nociceptive marker c-fos. Therefore, our aim was to simulate the human GTN migraine model in awake rats using a clinically relevant dose.
OriginalsprogEngelsk
TidsskriftCephalalgia : an international journal of headache
Vol/bind32
Udgave nummer1
Sider (fra-til)73-84
Antal sider12
DOI
StatusUdgivet - jan. 2012

ID: 47927838