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A new achiral reagent for the incorporation of multiple amino groups into oligonucleotides

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  • Carsten Behrens
  • Kenneth H. Petersen
  • Michael Egholm
  • Nielsen, John
  • Ole Buchard
  • Otto Dahl

The synthesis of a new functionalized achiral linker reagent (10) for the incorporation of multiple primary amino groups into oligonucleotides is described. The linker reagent is compatible with conventional DNA-synthesis following the phosphoramidite methodology, and the linker can be incorporated in good yield.

OriginalsprogEngelsk
TidsskriftBioorganic & Medicinal Chemistry Letters
Vol/bind5
Udgave nummer16
Sider (fra-til)1785-1790
Antal sider6
ISSN0960-894X
DOI
StatusUdgivet - 17 aug. 1995

ID: 249049