Forskning ved Københavns Universitet - Københavns Universitet

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A new look at lipid-membrane structure in relation to drug research

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Lipid-bilayer membranes are key objects in drug research in relation to (i) interaction of drugs with membrane-bound receptors, (ii) drug targeting, penetration, and permeation of cell membranes, and (iii) use of liposomes in micro-encapsulation technologies for drug delivery. Rational design of new drugs and drug-delivery systems therefore requires insight into the physical properties of lipid-bilayer membranes. This mini-review provides a perspective on the current view of lipid-bilayer structure and dynamics based on information obtained from a variety of recent experimental and theoretical studies. Special attention is paid to trans-bilayer structure, lateral molecular organization of the lipid bilayer, lipid-mediated protein assembly and lipid-bilayer permeability. It is argued that lipids play a major role in lipid membrane-organization and functionality.

OriginalsprogEngelsk
TidsskriftPharmaceutical Research
Vol/bind15
Udgave nummer10
Sider (fra-til)1507-1519
Antal sider13
ISSN0724-8741
DOI
StatusUdgivet - 21 okt. 1998

ID: 236886687