Forskning ved Københavns Universitet - Københavns Universitet


A new rapid and effective method for treatment of unexplained infertility

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • G. Edelstam
  • A. Sjosten
  • K. Bjuresten
  • I. Ek
  • K. Wanggren
  • J. Spira
BACKGROUND: Artificial insemination (intrauterine insemination by husband or artificial insemination by husband) is often tried as first treatment for couples with unexplained infertility. Perturbation has previously proved to increase the chance of achieving pregnancy for these couples. The effect of perturbation on fertility can be mechanical as well as anti-inflammatory by using a substance that inhibits phagocytosis of the spermatozoa. The objective of the study was to investigate the effect on pregnancy rate of pre-ovulatory perturbation with low-dose lignocaine during clomiphene citrate and insemination cycles for couples with unexplained infertility. METHODS: In a prospective, open study, the patients were randomized, the day before ovulation, during a clomiphene citrate stimulated cycle to either perturbation with low-dose local anaesthetic or no perturbation before insemination. RESULTS: A total of 130 cycles were studied, 67 of which were randomized to pre-ovulatory perturbation and 63 to no perturbation treatment. There were 14.9% (n = 10) clinical pregnancies in the perturbated group compared with 3.2% (n = 2) in the group without pre-ovulatory perturbation (P < 0.05). CONCLUSIONS: The perturbation treatment significantly enhanced the clinical pregnancy rate and was well tolerated. No complications were noted. The combined treatment of clomiphene citrate, perturbation and insemination can be used as a cost-effective, first-line treatment for couples with unexplained infertility
Udgivelsesdato: 2008/4
TidsskriftHuman Reproduction
Udgave nummer4
Sider (fra-til)852-856
Antal sider4
StatusUdgivet - 2008

Bibliografisk note

DA - 20080319IS - 1460-2350 (Electronic)LA - engPT - Comparative StudyPT - Journal ArticlePT - Randomized Controlled TrialRN - 0 (Fertility Agents, Female)RN - 137-58-6 (Lidocaine)RN - 911-45-5 (Clomiphene)SB - IM

ID: 10959848