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A novel polymorphism of human complement component C3 detected by means of a monoclonal antibody

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A mouse monoclonal antibody, HAV 4-1, obtained after immunization of a BALB/c mouse with purified C3F, detected a novel genetic polymorphism of human complement component C3 in a simple immunoblotting system. The frequency of HAV 4-1-positive genes was 20.1%. Reactivity of HAV 4-1 was closely related to C3F, but certain individuals with the C3F allele did not react with HAV 4-1. Conversely, certain C3S homozygous individuals did react with HAV 4-1. The polymorphism detected by this monoclonal antibody is therefore different from the previously described polymorphism based on charge differences.

OriginalsprogEngelsk
TidsskriftImmunogenetics
Vol/bind23
Udgave nummer5
Sider (fra-til)322-5
Antal sider4
ISSN0093-7711
StatusUdgivet - 1986
Eksternt udgivetJa

ID: 180824471