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A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • A Alkhalaf
  • S J L Bakker
  • H J G Bilo
  • R O B Gans
  • G J Navis
  • D Postmus
  • C Forsblom
  • P H Groop
  • N Vionnet
  • S Hadjadj
  • M Marre
  • H H Parving
  • Pia Rossing
  • Lise Tarnow
Homozygosity for a five leucine repeat (5L-5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We prospectively investigated in patients with type 1 diabetes whether: (1) 5L-5L is associated with mortality; (2) there is an interaction of 5L-5L with DN or sex for prediction of mortality; and (3) 5L-5L is associated with progression to end-stage renal disease (ESRD).
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind53
Udgave nummer12
Sider (fra-til)2562-8
Antal sider7
ISSN0012-186X
DOI
StatusUdgivet - 1 dec. 2010

ID: 34163419