Forskning ved Københavns Universitet - Københavns Universitet

Forside

A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

A protocol for rapid and efficient Pd/Cu-catalyzed coupling of aryl bromides and iodides to terminal alkynes has been developed with use of 2-(di-tert-butylphosphino)-N-phenylindole (cataCXium PIntB) as ligand in TMEDA and water. The new protocol successfully couples substrates which failed with standard Sonogashira conditions, and enables an efficient general synthetic route to free fatty acid 1 (FFA1) receptor ligands from 3-(4-bromophenyl)propionic acid.
OriginalsprogEngelsk
TidsskriftJournal of Organic Chemistry
Vol/bind75
Udgave nummer4
Sider (fra-til)1301-1304
Antal sider4
ISSN0022-3263
DOI
StatusUdgivet - 19 feb. 2010
Eksternt udgivetJa

ID: 189162076