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A role for the weak DnaA binding sites in bacterial replication origins

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DnaA initiates the chromosomal DNA replication in nearly all bacteria, and replication origins are characterized by binding sites for the DnaA protein (DnaA-boxes) along with an 'AT-rich' region. However, great variation in number, spatial organization and specificity of DnaA-boxes is observed between species. In the study by Taylor et al. (2011), new and unexpectedly weak DnaA-boxes were identified within the Caulobacter crescentus origin of replication (Cori). The position of weak and stronger DnaA-boxes follows a pattern seen in Escherichia coli oriC. This raises the possibility that bacterial origins might be more alike than previously thought.

TidsskriftMolecular Microbiology
Udgave nummer2
Sider (fra-til)272-274
Antal sider3
StatusUdgivet - 2011
Eksternt udgivetJa

ID: 200971366