Forskning ved Københavns Universitet - Københavns Universitet

Forside

A simplified laminin nomenclature

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Monique Aumailley
  • Leena Bruckner-Tudermann
  • William G. Carter
  • Rainer Deutzmann
  • David Edgar
  • Peter Ekblom
  • Jürgen Engels
  • Eva Engvall
  • Erhard Hohenester
  • Jonathan C.R. Jones
  • Hynda K. Kleinman
  • M. Peter Marinkovich
  • George R. Martin
  • Ulrike Mayer
  • Guerrino Meneguzzi
  • Jeffrey H. Miner
  • Kaoru Miyazaki
  • Manuel Patarroyo
  • Mats Paulsson
  • Vito Quaranta
  • Og 12 flere
  • Joshua R. Sanes
  • Takako Sasaki
  • Kiyotoshi Sekiguchi
  • Lydia M. Sorokin
  • Jan Fredrik Talts
  • Karl Tryggvason
  • Jouni Uitto
  • Ismo Virtanen
  • Klauv von der Mark
  • U Wewer
  • Yoshihiko Yamada
  • Peter D. Yurchenco
A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers composed of alpha, beta and gamma chains. Previously, laminin trimers were numbered with Arabic numerals in the order discovered, that is laminins-1 to -5. We introduce a new identification system for a trimer using three Arabic numerals, based on the alpha, beta and gamma chain numbers. For example, the laminin with the chain composition alpha5beta1gamma1 is termed laminin-511, and not laminin-10. The current practice is also to mix two overlapping domain and module nomenclatures. Instead of the older Roman numeral nomenclature and mixed nomenclature, all modules are now called domains. Some domains are renamed or renumbered. Laminin epidermal growth factor-like (LE) domains are renumbered starting at the N-termini, to be consistent with general protein nomenclature. Domain IVb of alpha chains is named laminin 4a (L4a), domain IVa of alpha chains is named L4b, domain IV of gamma chains is named L4, and domain IV of beta chains is named laminin four (LF). The two coiled-coil domains I and II are now considered one laminin coiled-coil domain (LCC). The interruption in the coiled-coil of beta chains is named laminin beta-knob (Lbeta) domain. The chain origin of a domain is specified by the chain nomenclature, such as alpha1L4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered.
OriginalsprogEngelsk
TidsskriftMatrix Biology
Vol/bind24
Udgave nummer5
Sider (fra-til)326-332
Antal sider7
ISSN0945-053X
DOI
StatusUdgivet - 2005

ID: 8001815