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A stem cell gene expression profile of human squamous cell carcinomas

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To investigate the relationship between stem cells in normal epithelium and in squamous cell carcinomas (SCCs), we examined expression of a panel of human epidermal stem cell markers in SCCs and SCC cell lines. Markers that are co-expressed in normal stem cells were not co-expressed in SCC. Downregulation of two markers, Lrig1 and MAP4, and upregulation of a third, MCSP, correlated with poor differentiation status and increased proliferation in primary tumours. We conclude that SCCs do not reflect a simple expansion of stem cells; rather, tumour cells hijack the homeostatic controls that operate in normal stem cells, eliminating those that maintain stem cell quiescence.
OriginalsprogEngelsk
TidsskriftCancer Letters
Vol/bind272
Udgave nummer1
Sider (fra-til)23-31
Antal sider9
ISSN0304-3835
DOI
StatusUdgivet - 8 dec. 2008
Eksternt udgivetJa

ID: 94415277