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Absorption and metabolism of the absorption enhancer didecanoylphosphatidylcholine in rabbit nasal epithelium in vivo

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The absorption enhancer, didecanoylphosphatidylcholine (DDPC), improves the nasal absorption of human growth hormone in rabbits. We elucidated the uptake and the metabolism of 1,2-di[1-C]decanoyl-L-3-phosphatidylcholine and 1,2-didecanoyl-L-3-phosphatidyl[N-methyl-H]choline in rabbit nasal mucosa in vivo. One minute after nasal application of DDPC, 4.4-7.5% of the applied dose was found absorbed into the mucosa. The retained radioactivity left the tissue in
OriginalsprogEngelsk
TidsskriftDrug Metabolism and Disposition
Vol/bind25
Udgave nummer9
Sider (fra-til)1083-1088
Antal sider6
ISSN0090-9556
StatusUdgivet - 1 jan. 1997

ID: 45562023