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Absorption kinetics and steady-state plasma concentrations of theophylline following therapeutic doses of two sustained-release preparations

Publikation: Bidrag til tidsskriftTidsskriftartikel

Standard

Absorption kinetics and steady-state plasma concentrations of theophylline following therapeutic doses of two sustained-release preparations. / Andersen, O; Nielsen, M K; Eriksen, P B; Fenger, M; Knudsen, P J.

I: Journal of Pharmaceutical Sciences, Bind 72, Nr. 2, 1983, s. 158-61.

Publikation: Bidrag til tidsskriftTidsskriftartikel

Harvard

Andersen, O, Nielsen, MK, Eriksen, PB, Fenger, M & Knudsen, PJ 1983, 'Absorption kinetics and steady-state plasma concentrations of theophylline following therapeutic doses of two sustained-release preparations', Journal of Pharmaceutical Sciences, bind 72, nr. 2, s. 158-61.

APA

Andersen, O., Nielsen, M. K., Eriksen, P. B., Fenger, M., & Knudsen, P. J. (1983). Absorption kinetics and steady-state plasma concentrations of theophylline following therapeutic doses of two sustained-release preparations. Journal of Pharmaceutical Sciences, 72(2), 158-61.

Vancouver

Andersen O, Nielsen MK, Eriksen PB, Fenger M, Knudsen PJ. Absorption kinetics and steady-state plasma concentrations of theophylline following therapeutic doses of two sustained-release preparations. Journal of Pharmaceutical Sciences. 1983;72(2):158-61.

Author

Andersen, O ; Nielsen, M K ; Eriksen, P B ; Fenger, M ; Knudsen, P J. / Absorption kinetics and steady-state plasma concentrations of theophylline following therapeutic doses of two sustained-release preparations. I: Journal of Pharmaceutical Sciences. 1983 ; Bind 72, Nr. 2. s. 158-61.

Bibtex

@article{50dc1211eac947f4865f8131e99c5fe8,
title = "Absorption kinetics and steady-state plasma concentrations of theophylline following therapeutic doses of two sustained-release preparations",
abstract = "Ten healthy volunteers received two sustained-release preparations as a single and multiple dose regimen in an open crossover study. Plasma theophylline concentrations were measured by an enzyme immunoassay. The limited fluctuation of the theophylline levels at steady state, with twice daily administration, clearly demonstrated the marked sustained release properties of both preparations. Results indicate similar properties for the two preparations. Significant correlations between the single dose period and steady state were found for Cmax and AUC (r = 0.76 and 0.87, respectively) with one formulation, whereas this was not the case for the other (r = 0.27 and 0.49). The daily dose necessary to keep the plasma concentration within the therapeutic range of 55-110 mumole/liter varied from 7.9 to 22.9 mg/kg. Only mild side effects were recorded, but they were not correlated to the plasma theophylline concentration.",
author = "O Andersen and Nielsen, {M K} and Eriksen, {P B} and M Fenger and Knudsen, {P J}",
year = "1983",
language = "English",
volume = "72",
pages = "158--61",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Absorption kinetics and steady-state plasma concentrations of theophylline following therapeutic doses of two sustained-release preparations

AU - Andersen, O

AU - Nielsen, M K

AU - Eriksen, P B

AU - Fenger, M

AU - Knudsen, P J

PY - 1983

Y1 - 1983

N2 - Ten healthy volunteers received two sustained-release preparations as a single and multiple dose regimen in an open crossover study. Plasma theophylline concentrations were measured by an enzyme immunoassay. The limited fluctuation of the theophylline levels at steady state, with twice daily administration, clearly demonstrated the marked sustained release properties of both preparations. Results indicate similar properties for the two preparations. Significant correlations between the single dose period and steady state were found for Cmax and AUC (r = 0.76 and 0.87, respectively) with one formulation, whereas this was not the case for the other (r = 0.27 and 0.49). The daily dose necessary to keep the plasma concentration within the therapeutic range of 55-110 mumole/liter varied from 7.9 to 22.9 mg/kg. Only mild side effects were recorded, but they were not correlated to the plasma theophylline concentration.

AB - Ten healthy volunteers received two sustained-release preparations as a single and multiple dose regimen in an open crossover study. Plasma theophylline concentrations were measured by an enzyme immunoassay. The limited fluctuation of the theophylline levels at steady state, with twice daily administration, clearly demonstrated the marked sustained release properties of both preparations. Results indicate similar properties for the two preparations. Significant correlations between the single dose period and steady state were found for Cmax and AUC (r = 0.76 and 0.87, respectively) with one formulation, whereas this was not the case for the other (r = 0.27 and 0.49). The daily dose necessary to keep the plasma concentration within the therapeutic range of 55-110 mumole/liter varied from 7.9 to 22.9 mg/kg. Only mild side effects were recorded, but they were not correlated to the plasma theophylline concentration.

M3 - Journal article

VL - 72

SP - 158

EP - 161

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 2

ER -

ID: 34097984