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Accelerated cerebral white matter development in preterm infants: a voxel-based morphometry study with diffusion tensor MR imaging

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Mónica Giménez
  • Maria J Miranda
  • A Peter Born
  • Zoltan Nagy
  • Egill Rostrup
  • Terry L Jernigan
  • Maria J Miranda
Twenty-seven preterm infants were compared to 10 full-term infants at term equivalent age using a voxel-based analysis of diffusion tensor imaging of the brain. Preterm infants exhibited higher fractional anisotropy values, which may suggest accelerated maturation, in the location of the sagittal stratum. While some earlier findings in preterm infants have suggested developmental delays, the results of this study are more consistent with accelerated white matter development, possibly as a result of increased sensorimotor stimulation in the extrauterine environment. These results are the first to suggest that the increased intensity of stimulation associated with preterm birth may advance the process of white matter maturation in the human brain. Questions remain about whether these findings reflect acceleration of the process of white matter maturation generally, or localized alterations induced specifically by activity in affected pathways
Udgivelsesdato: 2008/7/1
OriginalsprogEngelsk
TidsskriftNeuroImage
Vol/bind41
Udgave nummer3
Sider (fra-til)728-34
Antal sider6
ISSN1053-8119
DOI
StatusUdgivet - 2008

ID: 10949756