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Accessing complexity: the dynamics of virus-specific T cell responses

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Standard

Accessing complexity: the dynamics of virus-specific T cell responses. / Doherty, P C; Christensen, Jan Pravsgaard.

I: Annual Review of Immunology, Bind 18, 2000, s. 561-92.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Doherty, PC & Christensen, JP 2000, 'Accessing complexity: the dynamics of virus-specific T cell responses', Annual Review of Immunology, bind 18, s. 561-92. https://doi.org/10.1146/annurev.immunol.18.1.561

APA

Doherty, P. C., & Christensen, J. P. (2000). Accessing complexity: the dynamics of virus-specific T cell responses. Annual Review of Immunology, 18, 561-92. https://doi.org/10.1146/annurev.immunol.18.1.561

Vancouver

Doherty PC, Christensen JP. Accessing complexity: the dynamics of virus-specific T cell responses. Annual Review of Immunology. 2000;18:561-92. https://doi.org/10.1146/annurev.immunol.18.1.561

Author

Doherty, P C ; Christensen, Jan Pravsgaard. / Accessing complexity: the dynamics of virus-specific T cell responses. I: Annual Review of Immunology. 2000 ; Bind 18. s. 561-92.

Bibtex

@article{72310170df6811ddb5fc000ea68e967b,
title = "Accessing complexity: the dynamics of virus-specific T cell responses",
abstract = "The cellular dynamics of the immune system are complex and difficult to measure. Access to this problematic area has been greatly enhanced by the recent development of tetrameric complexes of MHC class I glycoprotein + peptide (tetramers) for the direct staining of freshly isolated, antigen-specific CD8(+ )T cells. Analysis to date with both naturally acquired and experimentally induced infections has established that the numbers of virus-specific CD8(+) T cells present during both the acute and memory phases of the host response are more than tenfold in excess of previously suspected values. The levels are such that the virus-specific CD8(+) set is readily detected in the human peripheral blood lymphocyte compartment, particularly during persistent infections. Experimentally, it is now possible to measure the extent of cycling for tetramer (+)CD8(+) T cells during the acute and memory phases of the host response to viruses. Dissection of the phenotypic, functional, and molecular diversity of CD8(+) T cell populations has been greatly facilitated. It is hoped it will also soon be possible to analyze CD4(+) T cell populations in this way. Though these are early days and there is an enormous amount to be done, our perceptions of the shape of virus-specific cell-mediated immunity are changing rapidly.",
author = "Doherty, {P C} and Christensen, {Jan Pravsgaard}",
note = "Keywords: Animals; CD8-Positive T-Lymphocytes; Humans; Immunologic Memory; T-Lymphocytes; Viruses",
year = "2000",
doi = "10.1146/annurev.immunol.18.1.561",
language = "English",
volume = "18",
pages = "561--92",
journal = "Annual Review of Immunology",
issn = "0732-0582",
publisher = "Annual Reviews, inc.",

}

RIS

TY - JOUR

T1 - Accessing complexity: the dynamics of virus-specific T cell responses

AU - Doherty, P C

AU - Christensen, Jan Pravsgaard

N1 - Keywords: Animals; CD8-Positive T-Lymphocytes; Humans; Immunologic Memory; T-Lymphocytes; Viruses

PY - 2000

Y1 - 2000

N2 - The cellular dynamics of the immune system are complex and difficult to measure. Access to this problematic area has been greatly enhanced by the recent development of tetrameric complexes of MHC class I glycoprotein + peptide (tetramers) for the direct staining of freshly isolated, antigen-specific CD8(+ )T cells. Analysis to date with both naturally acquired and experimentally induced infections has established that the numbers of virus-specific CD8(+) T cells present during both the acute and memory phases of the host response are more than tenfold in excess of previously suspected values. The levels are such that the virus-specific CD8(+) set is readily detected in the human peripheral blood lymphocyte compartment, particularly during persistent infections. Experimentally, it is now possible to measure the extent of cycling for tetramer (+)CD8(+) T cells during the acute and memory phases of the host response to viruses. Dissection of the phenotypic, functional, and molecular diversity of CD8(+) T cell populations has been greatly facilitated. It is hoped it will also soon be possible to analyze CD4(+) T cell populations in this way. Though these are early days and there is an enormous amount to be done, our perceptions of the shape of virus-specific cell-mediated immunity are changing rapidly.

AB - The cellular dynamics of the immune system are complex and difficult to measure. Access to this problematic area has been greatly enhanced by the recent development of tetrameric complexes of MHC class I glycoprotein + peptide (tetramers) for the direct staining of freshly isolated, antigen-specific CD8(+ )T cells. Analysis to date with both naturally acquired and experimentally induced infections has established that the numbers of virus-specific CD8(+) T cells present during both the acute and memory phases of the host response are more than tenfold in excess of previously suspected values. The levels are such that the virus-specific CD8(+) set is readily detected in the human peripheral blood lymphocyte compartment, particularly during persistent infections. Experimentally, it is now possible to measure the extent of cycling for tetramer (+)CD8(+) T cells during the acute and memory phases of the host response to viruses. Dissection of the phenotypic, functional, and molecular diversity of CD8(+) T cell populations has been greatly facilitated. It is hoped it will also soon be possible to analyze CD4(+) T cell populations in this way. Though these are early days and there is an enormous amount to be done, our perceptions of the shape of virus-specific cell-mediated immunity are changing rapidly.

U2 - 10.1146/annurev.immunol.18.1.561

DO - 10.1146/annurev.immunol.18.1.561

M3 - Journal article

C2 - 10837069

VL - 18

SP - 561

EP - 592

JO - Annual Review of Immunology

JF - Annual Review of Immunology

SN - 0732-0582

ER -

ID: 9639542