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Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients

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Skeletal muscle mass is controlled by myostatin and Akt-dependent signaling on mammalian target of rapamycin (mTOR), glycogen synthase kinase 3ß (GSK3ß) and forkhead box O (FoxO) pathways, but it is unknown how these pathways are regulated in critically ill human muscle. To describe factors involved in muscle mass regulation, we investigated the phosphorylation and expression of key factors in these protein synthesis and breakdown signaling pathways in thigh skeletal muscle of critically ill intensive care unit (ICU) patients compared with healthy controls.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind6
Udgave nummer3
Sider (fra-til)e18090
ISSN1932-6203
DOI
StatusUdgivet - 2011

ID: 40170843