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Activated T lymphocytes disappear from circulation during endotoxemia in humans

Publikation: Forskning - peer reviewTidsskriftartikel

Karen Suarez Krabbe, Helle Bruunsgaard Kemp, Jesper Qvist, Lise Fonsmark, Kirsten Møller, Christian Muff Hansen, Peter Skinhøj, Bente Klarlund Pedersen

Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.
OriginalsprogDansk
TidsskriftCLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
Vol/bind9
Tidsskriftsnummer3
Sider (fra-til)731-735
Antal sider5
ISSN1071-412X
StatusUdgivet - 31 dec. 2002

ID: 162988992