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Activated T lymphocytes disappear from circulation during endotoxemia in humans

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Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.
TidsskriftClinical and Vaccine Immunology
Udgave nummer3
Sider (fra-til)731-735
Antal sider5
StatusUdgivet - 31 dec. 2002

ID: 162988992