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Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans

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Standard

Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans. / Bagdade, John; Pedersen, Bente K; Schwenke, Dawn; Saremi, Aramesh; Alaupovic, Petar.

I: Scandinavian Journal of Clinical & Laboratory Investigation, Bind 71, Nr. 6, 2011, s. 449-55.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bagdade, J, Pedersen, BK, Schwenke, D, Saremi, A & Alaupovic, P 2011, 'Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans', Scandinavian Journal of Clinical & Laboratory Investigation, bind 71, nr. 6, s. 449-55. https://doi.org/10.3109/00365513.2011.585404

APA

Bagdade, J., Pedersen, B. K., Schwenke, D., Saremi, A., & Alaupovic, P. (2011). Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans. Scandinavian Journal of Clinical & Laboratory Investigation, 71(6), 449-55. https://doi.org/10.3109/00365513.2011.585404

Vancouver

Bagdade J, Pedersen BK, Schwenke D, Saremi A, Alaupovic P. Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans. Scandinavian Journal of Clinical & Laboratory Investigation. 2011;71(6):449-55. https://doi.org/10.3109/00365513.2011.585404

Author

Bagdade, John ; Pedersen, Bente K ; Schwenke, Dawn ; Saremi, Aramesh ; Alaupovic, Petar. / Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans. I: Scandinavian Journal of Clinical & Laboratory Investigation. 2011 ; Bind 71, Nr. 6. s. 449-55.

Bibtex

@article{052342fa847d45adb53215c42e0c274e,
title = "Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans",
abstract = "IL-6 is believed to mediate the elevation in plasma TG and VLDL lipids in patients with sepsis. Previous studies of lipoprotein density fractions do not reveal the extent to which cytokines change the immunochemically distinct TG-rich (LpB:C, LpB:C:E, LpAII:B:C:D:E) and cholesterol-rich (LpB, LpB:E) apoB-containing subclasses present in VLDL. Therefore, we have directly measured these subclasses following their isolation by sequential immunoprecipitation in seven healthy male subjects during a 3-h infusion with recombinant human (rh) IL-6. Though plasma TG and apoB-containing particle number were unchanged by IL-6, the distribution of TG-rich subclasses was significantly altered. Compared to baseline values, LpB:E + LpB:C:E increased significantly at 0.5 h (p <0.02) and were higher than saline-infused controls at 0.5 and 1 h (p <0.05). At 0.5 h LpAII:B:C:D:E reciprocally declined from baseline (p <0.01). While the pattern of change for total apoB showed an overall decline (p <0.05), these changes in LpB:E + LpB:C:E and LpAII:B:C:D:E in IL-6 subjects differed from controls (p <0.05; p <0.01, respectively). These findings indicate that physiologic concentrations of IL-6 rapidly and selectively regulate the transport of apoB particles that contain apoE. Since apoE has immunomodulatory and host defense functions, these changes may be a previously unrecognized early step in the innate immune response.",
author = "John Bagdade and Pedersen, {Bente K} and Dawn Schwenke and Aramesh Saremi and Petar Alaupovic",
year = "2011",
doi = "http://dx.doi.org/10.3109/00365513.2011.585404",
language = "English",
volume = "71",
pages = "449--55",
journal = "Scandinavian Journal of Clinical & Laboratory Investigation",
issn = "0036-5513",
publisher = "Taylor & Francis",
number = "6",

}

RIS

TY - JOUR

T1 - Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans

AU - Bagdade, John

AU - Pedersen, Bente K

AU - Schwenke, Dawn

AU - Saremi, Aramesh

AU - Alaupovic, Petar

PY - 2011

Y1 - 2011

N2 - IL-6 is believed to mediate the elevation in plasma TG and VLDL lipids in patients with sepsis. Previous studies of lipoprotein density fractions do not reveal the extent to which cytokines change the immunochemically distinct TG-rich (LpB:C, LpB:C:E, LpAII:B:C:D:E) and cholesterol-rich (LpB, LpB:E) apoB-containing subclasses present in VLDL. Therefore, we have directly measured these subclasses following their isolation by sequential immunoprecipitation in seven healthy male subjects during a 3-h infusion with recombinant human (rh) IL-6. Though plasma TG and apoB-containing particle number were unchanged by IL-6, the distribution of TG-rich subclasses was significantly altered. Compared to baseline values, LpB:E + LpB:C:E increased significantly at 0.5 h (p <0.02) and were higher than saline-infused controls at 0.5 and 1 h (p <0.05). At 0.5 h LpAII:B:C:D:E reciprocally declined from baseline (p <0.01). While the pattern of change for total apoB showed an overall decline (p <0.05), these changes in LpB:E + LpB:C:E and LpAII:B:C:D:E in IL-6 subjects differed from controls (p <0.05; p <0.01, respectively). These findings indicate that physiologic concentrations of IL-6 rapidly and selectively regulate the transport of apoB particles that contain apoE. Since apoE has immunomodulatory and host defense functions, these changes may be a previously unrecognized early step in the innate immune response.

AB - IL-6 is believed to mediate the elevation in plasma TG and VLDL lipids in patients with sepsis. Previous studies of lipoprotein density fractions do not reveal the extent to which cytokines change the immunochemically distinct TG-rich (LpB:C, LpB:C:E, LpAII:B:C:D:E) and cholesterol-rich (LpB, LpB:E) apoB-containing subclasses present in VLDL. Therefore, we have directly measured these subclasses following their isolation by sequential immunoprecipitation in seven healthy male subjects during a 3-h infusion with recombinant human (rh) IL-6. Though plasma TG and apoB-containing particle number were unchanged by IL-6, the distribution of TG-rich subclasses was significantly altered. Compared to baseline values, LpB:E + LpB:C:E increased significantly at 0.5 h (p <0.02) and were higher than saline-infused controls at 0.5 and 1 h (p <0.05). At 0.5 h LpAII:B:C:D:E reciprocally declined from baseline (p <0.01). While the pattern of change for total apoB showed an overall decline (p <0.05), these changes in LpB:E + LpB:C:E and LpAII:B:C:D:E in IL-6 subjects differed from controls (p <0.05; p <0.01, respectively). These findings indicate that physiologic concentrations of IL-6 rapidly and selectively regulate the transport of apoB particles that contain apoE. Since apoE has immunomodulatory and host defense functions, these changes may be a previously unrecognized early step in the innate immune response.

U2 - http://dx.doi.org/10.3109/00365513.2011.585404

DO - http://dx.doi.org/10.3109/00365513.2011.585404

M3 - Journal article

VL - 71

SP - 449

EP - 455

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

SN - 0036-5513

IS - 6

ER -

ID: 40188327