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Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

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Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines. / Aves, Kara Lee; Goksøyr, Louise; Sander, Adam F.

I: Viruses, Bind 12, Nr. 2, 185, 2020.

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Harvard

Aves, KL, Goksøyr, L & Sander, AF 2020, 'Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines', Viruses, bind 12, nr. 2, 185. https://doi.org/10.3390/v12020185

APA

Aves, K. L., Goksøyr, L., & Sander, A. F. (2020). Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines. Viruses, 12(2), [185]. https://doi.org/10.3390/v12020185

Vancouver

Aves KL, Goksøyr L, Sander AF. Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines. Viruses. 2020;12(2). 185. https://doi.org/10.3390/v12020185

Author

Aves, Kara Lee ; Goksøyr, Louise ; Sander, Adam F. / Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines. I: Viruses. 2020 ; Bind 12, Nr. 2.

Bibtex

@article{743bdd72c1184baf8e8f294d754015ff,
title = "Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines",
abstract = "Capsid-like particles (CLPs) are multimeric, repetitive assemblies of recombinant viral capsid proteins, which are highly immunogenic due to their structural similarity to wild-type viruses. CLPs can be used as molecular scaffolds to enable the presentation of soluble vaccine antigens in a similar structural format, which can significantly increase the immunogenicity of the antigen. CLP-based antigen display can be obtained by various genetic and modular conjugation methods. However, these vary in their versatility as well as efficiency in achieving an immunogenic antigen display. Here, we make a comparative review of the major CLP-based antigen display technologies. The Tag/Catcher-AP205 platform is highlighted as a particularly versatile and efficient technology that offers new qualitative and practical advantages in designing modular CLP vaccines. Finally, we discuss how split-protein Tag/Catcher conjugation systems can help to further propagate and enhance modular CLP vaccine designs.",
keywords = "capsid, antigen display, virus-like particle, vaccine, platform",
author = "Aves, {Kara Lee} and Louise Goks{\o}yr and Sander, {Adam F.}",
year = "2020",
doi = "10.3390/v12020185",
language = "English",
volume = "12",
journal = "Viruses",
issn = "1999-4915",
publisher = "M D P I AG",
number = "2",

}

RIS

TY - JOUR

T1 - Advantages and Prospects of Tag/Catcher Mediated Antigen Display on Capsid-Like Particle-Based Vaccines

AU - Aves, Kara Lee

AU - Goksøyr, Louise

AU - Sander, Adam F.

PY - 2020

Y1 - 2020

N2 - Capsid-like particles (CLPs) are multimeric, repetitive assemblies of recombinant viral capsid proteins, which are highly immunogenic due to their structural similarity to wild-type viruses. CLPs can be used as molecular scaffolds to enable the presentation of soluble vaccine antigens in a similar structural format, which can significantly increase the immunogenicity of the antigen. CLP-based antigen display can be obtained by various genetic and modular conjugation methods. However, these vary in their versatility as well as efficiency in achieving an immunogenic antigen display. Here, we make a comparative review of the major CLP-based antigen display technologies. The Tag/Catcher-AP205 platform is highlighted as a particularly versatile and efficient technology that offers new qualitative and practical advantages in designing modular CLP vaccines. Finally, we discuss how split-protein Tag/Catcher conjugation systems can help to further propagate and enhance modular CLP vaccine designs.

AB - Capsid-like particles (CLPs) are multimeric, repetitive assemblies of recombinant viral capsid proteins, which are highly immunogenic due to their structural similarity to wild-type viruses. CLPs can be used as molecular scaffolds to enable the presentation of soluble vaccine antigens in a similar structural format, which can significantly increase the immunogenicity of the antigen. CLP-based antigen display can be obtained by various genetic and modular conjugation methods. However, these vary in their versatility as well as efficiency in achieving an immunogenic antigen display. Here, we make a comparative review of the major CLP-based antigen display technologies. The Tag/Catcher-AP205 platform is highlighted as a particularly versatile and efficient technology that offers new qualitative and practical advantages in designing modular CLP vaccines. Finally, we discuss how split-protein Tag/Catcher conjugation systems can help to further propagate and enhance modular CLP vaccine designs.

KW - capsid, antigen display, virus-like particle, vaccine, platform

U2 - 10.3390/v12020185

DO - 10.3390/v12020185

M3 - Review

C2 - 32041299

AN - SCOPUS:85079242002

VL - 12

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 2

M1 - 185

ER -

ID: 236722537