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Age estimation based on aspartic acid racemization in elastin from the yellow ligaments

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Standard

Age estimation based on aspartic acid racemization in elastin from the yellow ligaments. / Ritz-Timme, S.; Laumeier, I.; Collins, M.

I: International Journal of Legal Medicine, Bind 117, Nr. 2, 2003, s. 96-101.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Ritz-Timme, S, Laumeier, I & Collins, M 2003, 'Age estimation based on aspartic acid racemization in elastin from the yellow ligaments', International Journal of Legal Medicine, bind 117, nr. 2, s. 96-101. https://doi.org/10.1007/s00414-002-0355-2

APA

Ritz-Timme, S., Laumeier, I., & Collins, M. (2003). Age estimation based on aspartic acid racemization in elastin from the yellow ligaments. International Journal of Legal Medicine, 117(2), 96-101. https://doi.org/10.1007/s00414-002-0355-2

Vancouver

Ritz-Timme S, Laumeier I, Collins M. Age estimation based on aspartic acid racemization in elastin from the yellow ligaments. International Journal of Legal Medicine. 2003;117(2):96-101. https://doi.org/10.1007/s00414-002-0355-2

Author

Ritz-Timme, S. ; Laumeier, I. ; Collins, M. / Age estimation based on aspartic acid racemization in elastin from the yellow ligaments. I: International Journal of Legal Medicine. 2003 ; Bind 117, Nr. 2. s. 96-101.

Bibtex

@article{8f2d9612009a4036b099a29b24982081,
title = "Age estimation based on aspartic acid racemization in elastin from the yellow ligaments",
abstract = "The yellow ligaments of the spine are characterized by an exceptionally high content of elastin, a protein with a proved longevity in several human tissues. This unique biochemical composition suggested a suitability of yellow ligaments for age estimation based on aspartic acid racemization (AAR), which was tested by determination of AAR in total tissue specimens and in purified elastin from yellow ligaments of individuals of known age. AAR was found to increase with age in both sample sets. The purified elastin samples exhibited a much faster kinetics than the total tissue, with ca. 3.7-4.6-fold higher apparent rates. The relationship between AAR and age was much closer in the purified elastin samples (r =0.96-0.99) and it can therefore be used as a basis for biochemical age estimation. The analysis of total tissue samples cannot be recommended since the AAR values can be strongly influenced even by slight, histologically non-detectable variations in the collagen content. Age estimation based on AAR in purified elastin from yellow ligaments may be a valuable additional tool in the identification of unidentified cadavers, especially in cases where other methods cannot be applied (e.g. no available teeth, body parts).",
keywords = "Age estimation, Aspartic acid racemization, Elastin, Yellow ligaments",
author = "S. Ritz-Timme and I. Laumeier and M. Collins",
year = "2003",
doi = "10.1007/s00414-002-0355-2",
language = "English",
volume = "117",
pages = "96--101",
journal = "International Journal of Legal Medicine (Print)",
issn = "0937-9827",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Age estimation based on aspartic acid racemization in elastin from the yellow ligaments

AU - Ritz-Timme, S.

AU - Laumeier, I.

AU - Collins, M.

PY - 2003

Y1 - 2003

N2 - The yellow ligaments of the spine are characterized by an exceptionally high content of elastin, a protein with a proved longevity in several human tissues. This unique biochemical composition suggested a suitability of yellow ligaments for age estimation based on aspartic acid racemization (AAR), which was tested by determination of AAR in total tissue specimens and in purified elastin from yellow ligaments of individuals of known age. AAR was found to increase with age in both sample sets. The purified elastin samples exhibited a much faster kinetics than the total tissue, with ca. 3.7-4.6-fold higher apparent rates. The relationship between AAR and age was much closer in the purified elastin samples (r =0.96-0.99) and it can therefore be used as a basis for biochemical age estimation. The analysis of total tissue samples cannot be recommended since the AAR values can be strongly influenced even by slight, histologically non-detectable variations in the collagen content. Age estimation based on AAR in purified elastin from yellow ligaments may be a valuable additional tool in the identification of unidentified cadavers, especially in cases where other methods cannot be applied (e.g. no available teeth, body parts).

AB - The yellow ligaments of the spine are characterized by an exceptionally high content of elastin, a protein with a proved longevity in several human tissues. This unique biochemical composition suggested a suitability of yellow ligaments for age estimation based on aspartic acid racemization (AAR), which was tested by determination of AAR in total tissue specimens and in purified elastin from yellow ligaments of individuals of known age. AAR was found to increase with age in both sample sets. The purified elastin samples exhibited a much faster kinetics than the total tissue, with ca. 3.7-4.6-fold higher apparent rates. The relationship between AAR and age was much closer in the purified elastin samples (r =0.96-0.99) and it can therefore be used as a basis for biochemical age estimation. The analysis of total tissue samples cannot be recommended since the AAR values can be strongly influenced even by slight, histologically non-detectable variations in the collagen content. Age estimation based on AAR in purified elastin from yellow ligaments may be a valuable additional tool in the identification of unidentified cadavers, especially in cases where other methods cannot be applied (e.g. no available teeth, body parts).

KW - Age estimation

KW - Aspartic acid racemization

KW - Elastin

KW - Yellow ligaments

U2 - 10.1007/s00414-002-0355-2

DO - 10.1007/s00414-002-0355-2

M3 - Journal article

C2 - 12690506

AN - SCOPUS:0038176380

VL - 117

SP - 96

EP - 101

JO - International Journal of Legal Medicine (Print)

JF - International Journal of Legal Medicine (Print)

SN - 0937-9827

IS - 2

ER -

ID: 232090098