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Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

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Standard

Age of First Arrhythmic Event in Brugada Syndrome : Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients. / Milman, Anat; Andorin, Antoine; Gourraud, Jean-Baptiste; Sacher, Frederic; Mabo, Philippe; Kim, Sung-Hwan; Maeda, Shingo; Takahashi, Yoshihide; Kamakura, Tsukasa; Aiba, Takeshi; Conte, Giulio; Juang, Jimmy J M; Leshem, Eran; Rahkovich, Michael; Hochstadt, Aviram; Mizusawa, Yuka; Postema, Pieter G; Arbelo, Elena; Huang, Zhengrong; Denjoy, Isabelle; Giustetto, Carla; Wijeyeratne, Yanushi D; Napolitano, Carlo; Michowitz, Yoav; Brugada, Ramon; Casado-Arroyo, Ruben; Champagne, Jean; Calo, Leonardo; Sarquella-Brugada, Georgia; Tfelt-Hansen, Jacob; Priori, Silvia G; Takagi, Masahiko; Veltmann, Christian; Delise, Pietro; Corrado, Domenico; Behr, Elijah R; Gaita, Fiorenzo; Yan, Gan-Xin; Brugada, Josep; Leenhardt, Antoine; Wilde, Arthur A M; Brugada, Pedro; Kusano, Kengo F; Hirao, Kenzo; Nam, Gi-Byoung; Probst, Vincent; Belhassen, Bernard.

I: Circulation. Arrhythmia and electrophysiology, Bind 10, Nr. 12, e005222, 12.2017.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Milman, A, Andorin, A, Gourraud, J-B, Sacher, F, Mabo, P, Kim, S-H, Maeda, S, Takahashi, Y, Kamakura, T, Aiba, T, Conte, G, Juang, JJM, Leshem, E, Rahkovich, M, Hochstadt, A, Mizusawa, Y, Postema, PG, Arbelo, E, Huang, Z, Denjoy, I, Giustetto, C, Wijeyeratne, YD, Napolitano, C, Michowitz, Y, Brugada, R, Casado-Arroyo, R, Champagne, J, Calo, L, Sarquella-Brugada, G, Tfelt-Hansen, J, Priori, SG, Takagi, M, Veltmann, C, Delise, P, Corrado, D, Behr, ER, Gaita, F, Yan, G-X, Brugada, J, Leenhardt, A, Wilde, AAM, Brugada, P, Kusano, KF, Hirao, K, Nam, G-B, Probst, V & Belhassen, B 2017, 'Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients', Circulation. Arrhythmia and electrophysiology, bind 10, nr. 12, e005222. https://doi.org/10.1161/CIRCEP.117.005222

APA

Milman, A., Andorin, A., Gourraud, J-B., Sacher, F., Mabo, P., Kim, S-H., ... Belhassen, B. (2017). Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients. Circulation. Arrhythmia and electrophysiology, 10(12), [e005222]. https://doi.org/10.1161/CIRCEP.117.005222

Vancouver

Milman A, Andorin A, Gourraud J-B, Sacher F, Mabo P, Kim S-H o.a. Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients. Circulation. Arrhythmia and electrophysiology. 2017 dec;10(12). e005222. https://doi.org/10.1161/CIRCEP.117.005222

Author

Milman, Anat ; Andorin, Antoine ; Gourraud, Jean-Baptiste ; Sacher, Frederic ; Mabo, Philippe ; Kim, Sung-Hwan ; Maeda, Shingo ; Takahashi, Yoshihide ; Kamakura, Tsukasa ; Aiba, Takeshi ; Conte, Giulio ; Juang, Jimmy J M ; Leshem, Eran ; Rahkovich, Michael ; Hochstadt, Aviram ; Mizusawa, Yuka ; Postema, Pieter G ; Arbelo, Elena ; Huang, Zhengrong ; Denjoy, Isabelle ; Giustetto, Carla ; Wijeyeratne, Yanushi D ; Napolitano, Carlo ; Michowitz, Yoav ; Brugada, Ramon ; Casado-Arroyo, Ruben ; Champagne, Jean ; Calo, Leonardo ; Sarquella-Brugada, Georgia ; Tfelt-Hansen, Jacob ; Priori, Silvia G ; Takagi, Masahiko ; Veltmann, Christian ; Delise, Pietro ; Corrado, Domenico ; Behr, Elijah R ; Gaita, Fiorenzo ; Yan, Gan-Xin ; Brugada, Josep ; Leenhardt, Antoine ; Wilde, Arthur A M ; Brugada, Pedro ; Kusano, Kengo F ; Hirao, Kenzo ; Nam, Gi-Byoung ; Probst, Vincent ; Belhassen, Bernard. / Age of First Arrhythmic Event in Brugada Syndrome : Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients. I: Circulation. Arrhythmia and electrophysiology. 2017 ; Bind 10, Nr. 12.

Bibtex

@article{149eca9be59a4987a98895a886ff77a0,
title = "Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients",
abstract = "BACKGROUND: Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the influence of the mode of AE documentation, sex, and ethnicity on the age at first AE.METHODS AND RESULTS: A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 patients with Brugada syndrome (91.3{\%} men) with first AE documented at time of aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation (group B, n=252). The vast majority (94.2{\%}) of the patients were 16 to 70 years old at the time of AE, whereas pediatric (<16 years) and elderly patients (>70 years) comprised 4.3{\%} and 1.5{\%}, respectively. Peak AE rate occurred between 38 and 48 years (mean, 41.9±14.8; range, 0.27-84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1±13.2 versus 39.4±15.0 years; P<0.001). In adult patients (≥16 years), women experienced AE 6.5 years later than men (P=0.003). Whites and Asians exhibited their AE at the same median age (43 years).CONCLUSIONS: SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) presents the first analysis on the age distribution of AE in Brugada syndrome, suggesting 2 age cutoffs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient sex, and ethnic origin on the age at AE.",
keywords = "Adolescent, Adult, Age of Onset, Aged, Brugada Syndrome/physiopathology, Defibrillators, Implantable, Female, Humans, Male, Middle Aged, Prognosis",
author = "Anat Milman and Antoine Andorin and Jean-Baptiste Gourraud and Frederic Sacher and Philippe Mabo and Sung-Hwan Kim and Shingo Maeda and Yoshihide Takahashi and Tsukasa Kamakura and Takeshi Aiba and Giulio Conte and Juang, {Jimmy J M} and Eran Leshem and Michael Rahkovich and Aviram Hochstadt and Yuka Mizusawa and Postema, {Pieter G} and Elena Arbelo and Zhengrong Huang and Isabelle Denjoy and Carla Giustetto and Wijeyeratne, {Yanushi D} and Carlo Napolitano and Yoav Michowitz and Ramon Brugada and Ruben Casado-Arroyo and Jean Champagne and Leonardo Calo and Georgia Sarquella-Brugada and Jacob Tfelt-Hansen and Priori, {Silvia G} and Masahiko Takagi and Christian Veltmann and Pietro Delise and Domenico Corrado and Behr, {Elijah R} and Fiorenzo Gaita and Gan-Xin Yan and Josep Brugada and Antoine Leenhardt and Wilde, {Arthur A M} and Pedro Brugada and Kusano, {Kengo F} and Kenzo Hirao and Gi-Byoung Nam and Vincent Probst and Bernard Belhassen",
note = "{\circledC} 2017 American Heart Association, Inc.",
year = "2017",
month = "12",
doi = "10.1161/CIRCEP.117.005222",
language = "English",
volume = "10",
journal = "Circulation: Arrhythmia and Electrophysiology",
issn = "1941-3149",
publisher = "Lippincott Williams & Wilkins",
number = "12",

}

RIS

TY - JOUR

T1 - Age of First Arrhythmic Event in Brugada Syndrome

T2 - Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

AU - Milman, Anat

AU - Andorin, Antoine

AU - Gourraud, Jean-Baptiste

AU - Sacher, Frederic

AU - Mabo, Philippe

AU - Kim, Sung-Hwan

AU - Maeda, Shingo

AU - Takahashi, Yoshihide

AU - Kamakura, Tsukasa

AU - Aiba, Takeshi

AU - Conte, Giulio

AU - Juang, Jimmy J M

AU - Leshem, Eran

AU - Rahkovich, Michael

AU - Hochstadt, Aviram

AU - Mizusawa, Yuka

AU - Postema, Pieter G

AU - Arbelo, Elena

AU - Huang, Zhengrong

AU - Denjoy, Isabelle

AU - Giustetto, Carla

AU - Wijeyeratne, Yanushi D

AU - Napolitano, Carlo

AU - Michowitz, Yoav

AU - Brugada, Ramon

AU - Casado-Arroyo, Ruben

AU - Champagne, Jean

AU - Calo, Leonardo

AU - Sarquella-Brugada, Georgia

AU - Tfelt-Hansen, Jacob

AU - Priori, Silvia G

AU - Takagi, Masahiko

AU - Veltmann, Christian

AU - Delise, Pietro

AU - Corrado, Domenico

AU - Behr, Elijah R

AU - Gaita, Fiorenzo

AU - Yan, Gan-Xin

AU - Brugada, Josep

AU - Leenhardt, Antoine

AU - Wilde, Arthur A M

AU - Brugada, Pedro

AU - Kusano, Kengo F

AU - Hirao, Kenzo

AU - Nam, Gi-Byoung

AU - Probst, Vincent

AU - Belhassen, Bernard

N1 - © 2017 American Heart Association, Inc.

PY - 2017/12

Y1 - 2017/12

N2 - BACKGROUND: Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the influence of the mode of AE documentation, sex, and ethnicity on the age at first AE.METHODS AND RESULTS: A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 patients with Brugada syndrome (91.3% men) with first AE documented at time of aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation (group B, n=252). The vast majority (94.2%) of the patients were 16 to 70 years old at the time of AE, whereas pediatric (<16 years) and elderly patients (>70 years) comprised 4.3% and 1.5%, respectively. Peak AE rate occurred between 38 and 48 years (mean, 41.9±14.8; range, 0.27-84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1±13.2 versus 39.4±15.0 years; P<0.001). In adult patients (≥16 years), women experienced AE 6.5 years later than men (P=0.003). Whites and Asians exhibited their AE at the same median age (43 years).CONCLUSIONS: SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) presents the first analysis on the age distribution of AE in Brugada syndrome, suggesting 2 age cutoffs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient sex, and ethnic origin on the age at AE.

AB - BACKGROUND: Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the influence of the mode of AE documentation, sex, and ethnicity on the age at first AE.METHODS AND RESULTS: A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 patients with Brugada syndrome (91.3% men) with first AE documented at time of aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation (group B, n=252). The vast majority (94.2%) of the patients were 16 to 70 years old at the time of AE, whereas pediatric (<16 years) and elderly patients (>70 years) comprised 4.3% and 1.5%, respectively. Peak AE rate occurred between 38 and 48 years (mean, 41.9±14.8; range, 0.27-84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1±13.2 versus 39.4±15.0 years; P<0.001). In adult patients (≥16 years), women experienced AE 6.5 years later than men (P=0.003). Whites and Asians exhibited their AE at the same median age (43 years).CONCLUSIONS: SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) presents the first analysis on the age distribution of AE in Brugada syndrome, suggesting 2 age cutoffs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient sex, and ethnic origin on the age at AE.

KW - Adolescent

KW - Adult

KW - Age of Onset

KW - Aged

KW - Brugada Syndrome/physiopathology

KW - Defibrillators, Implantable

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

U2 - 10.1161/CIRCEP.117.005222

DO - 10.1161/CIRCEP.117.005222

M3 - Journal article

C2 - 29254945

VL - 10

JO - Circulation: Arrhythmia and Electrophysiology

JF - Circulation: Arrhythmia and Electrophysiology

SN - 1941-3149

IS - 12

M1 - e005222

ER -

ID: 196008934