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Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Konstantina Dimakopoulou
  • Evangelia Samoli
  • Rob Beelen
  • Massimo Stafoggia
  • Barbara Hoffmann
  • Paul Fischer
  • Mark Nieuwenhuijsen
  • Paolo Vineis
  • Wei Xun
  • Gerard Hoek
  • Ole Raaschou-Nielsen
  • Anna Oudin
  • Bertil Forsberg
  • Lars Modig
  • Pekka Jousilahti
  • Timo Lanki
  • Anu Turunen
  • Bente Oftedal
  • Per Nafstad
  • Per E Schwarze
  • Johanna Penell
  • Laura Fratiglioni
  • Niklas Andersson
  • Nancy Pedersen
  • Michal Korek
  • Ulf De Faire
  • Kirsten Thorup Eriksen
  • Anne Tjønneland
  • Thomas Becker
  • Meng Wang
  • Bas Bueno-de-Mesquita
  • Ming-Yi Tsai
  • Marloes Eeftens
  • Petra H Peeters
  • Kees Meliefste
  • Alessandro Marcon
  • Ursula Krämer
  • Thomas Aj Kuhlbusch
  • Mohammad Vossoughi
  • Timothy Key
  • Kees de Hoogh
  • Regina Hampel
  • Annette Peters
  • Joachim Heinrich
  • Gudrun Weinmayr
  • Hans Concin
  • Gabriele Nagel
  • Alex Ineichen
  • Bénédicte Jacquemin
  • Morgane Stempfelet
  • Alice Vilier
  • Fulvio Ricceri
  • Carlotta Sacerdote
  • Xanthi Pedeli
  • Michalis Katsoulis
  • Antonia Trichopoulou
  • Bert Brunekreef
  • Klea Katsouyanni
Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic related air pollution is associated with reduced survival. However, the effects on non-malignant respiratory mortality are less studied and those reported are less consistent. Objectives: We have investigated the relationship of long-term exposure to air pollution and non-malignant respiratory mortality in 16 cohorts with individual level data within the multi center European Study of Cohorts for Air Pollution Effects (ESCAPE). Methods: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up. Measurements: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases, following a standardized procedure within ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using meta-analyses. Main Results: We found no significant associations between air pollution exposure and non-malignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators. Conclusions: In this study of 16 cohorts there was no association between air pollution exposure and non malignant respiratory mortality.
OriginalsprogEngelsk
TidsskriftAmerican Journal of Respiratory and Critical Care Medicine
Vol/bind189
Udgave nummer6
Sider (fra-til)684-696
Antal sider13
ISSN1073-449X
DOI
StatusUdgivet - 15 mar. 2014

ID: 101683162