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Alcohol binge drinking in early pregnancy and the effect on fetal growth: a cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Julie A. Slavensky
  • Ulrik S. Kesmodel

Introduction: Alcohol binge drinking is common in early pregnancy and is a well-established risk factor for subsequent child health. Yet, very few studies have investigated the effect on fetal growth. Furthermore, it has been speculated that the timing of binge drinking may be a determining factor for neonatal growth. The objective of this study was to assess the potential effect of binge drinking and different drinking patterns (timing and number of binge drinking episodes) in early pregnancy on fetal growth estimated by birthweight and birth length. Material and methods: From 1 March to 31 August 2000, 1836 pregnant Danish women from Aarhus University Hospital and Fredericia Hospital were included in the study and interviewed around the early second trimester about their drinking habits during their pregnancy. Information on anthropometric measures at birth was obtained from the Danish Medical Birth Registry. The potential effect of binge drinking and different drinking patterns was estimated using a multivariate general linear regression model adjusted for potential confounders that were selected a priori based on the currently available scientific literature. Results: The women who reported any binge drinking gave birth to children with a reduction in birth length of −0.02 cm (95% CI −0.23 to 0.18) and an increase in birthweight of 0.2 g (95% CI −42.8 to 43.2). The number of binge episodes and the timing of these episodes were also not associated with fetal growth. Conclusions: The study suggests that binge drinking and different drinking patterns in early pregnancy do not affect fetal growth.

OriginalsprogEngelsk
TidsskriftActa Obstetricia et Gynecologica Scandinavica
Vol/bind97
Udgave nummer4
Sider (fra-til)477-482
ISSN0001-6349
DOI
StatusUdgivet - 2018

ID: 200291794