Forskning ved Københavns Universitet - Københavns Universitet


Alcohol septal ablation in patients with severe septal hypertrophy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Josef Veselka
  • Morten Jensen
  • Max Liebregts
  • Robert M. Cooper
  • Jaroslav Januska
  • Maksim Kashtanov
  • MacIej Dabrowski
  • Hansen, Peter Riis
  • Hubert Seggewiss
  • Eva Hansvenclova
  • Bundgård, Henning
  • Jurrien Ten Berg
  • Rodney Hilton Stables
  • Lothar Faber

Objective: The current guidelines suggest alcohol septal ablation (ASA) is less effective in hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular hypertrophy, despite acknowledging that systematic data are lacking. Therefore, we analysed patients in the Euro-ASA registry to test this statement. Methods: We compared the short-term and long-term outcomes of patients with basal interventricular septum (IVS) thickness <30 mm Hg to those with ≥30 mm Hg treated using ASA in nine European centres. Results: A total of 1519 patients (57±14 years, 49% women) with symptomatic HOCM were treated, including 67 (4.4%) patients with IVS thickness ≥30 mm. The occurrence of short-term major adverse events were similar in both groups. The mean follow-up was 5.4±4.3 years and 5.1±4.1 years, and the all-cause mortality rate was 2.57 and 2.94 deaths per 100 person-years of follow-up in the IVS <30 mm group and the IVS ≥30 mm group (p=0.047), respectively. There were no differences in dyspnoea (New York Heart Association class III/IV 12% vs 16%), residual left ventricular outflow tract gradient (16±20 vs 16±16 mm Hg) and repeated septal reduction procedures (12% vs 18%) in the IVS <30 mm group and IVS ≥30 mm group, respectively (p=NS for all). Conclusions: The short-term results and the long-term relief of dyspnoea, residual left ventricular outflow obstruction and occurrence of repeated septal reduction procedures in patients with basal IVS ≥30 mm is similar to those with IVS <30mm. However, long-term all-cause and cardiac mortality rates are worse in the ≥30 mm group.

StatusE-pub ahead of print - 2020

ID: 236317413