Forskning ved Københavns Universitet - Københavns Universitet

Forside

alpha-Endosulfine, a new entity in the control of insulin secretion.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

alpha-Endosulfine, a new entity in the control of insulin secretion. / Bataille, D; Héron, L; Virsolvy, A; Peyrollier, K; LeCam, A; Gros, L; Blache, P.

I: Cellular and Molecular Life Sciences, Bind 56, Nr. 1-2, 1999, s. 78-84.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bataille, D, Héron, L, Virsolvy, A, Peyrollier, K, LeCam, A, Gros, L & Blache, P 1999, 'alpha-Endosulfine, a new entity in the control of insulin secretion.', Cellular and Molecular Life Sciences, bind 56, nr. 1-2, s. 78-84.

APA

Bataille, D., Héron, L., Virsolvy, A., Peyrollier, K., LeCam, A., Gros, L., & Blache, P. (1999). alpha-Endosulfine, a new entity in the control of insulin secretion. Cellular and Molecular Life Sciences, 56(1-2), 78-84.

Vancouver

Bataille D, Héron L, Virsolvy A, Peyrollier K, LeCam A, Gros L o.a. alpha-Endosulfine, a new entity in the control of insulin secretion. Cellular and Molecular Life Sciences. 1999;56(1-2):78-84.

Author

Bataille, D ; Héron, L ; Virsolvy, A ; Peyrollier, K ; LeCam, A ; Gros, L ; Blache, P. / alpha-Endosulfine, a new entity in the control of insulin secretion. I: Cellular and Molecular Life Sciences. 1999 ; Bind 56, Nr. 1-2. s. 78-84.

Bibtex

@article{4e3917205d6411dd8d9f000ea68e967b,
title = "alpha-Endosulfine, a new entity in the control of insulin secretion.",
abstract = "ATP-dependent potassium (K ATP) channels occupy a key position in the control of insulin release from the pancreatic beta cell since they couple cell polarity to metabolism. These channels close when more ATP is produced via glucose metabolism. They are also controlled by sulfonylureas, a class of drugs used in type 2 diabetic patients for triggering insulin secretion from beta cells that have lost part of their sensitivity to glucose. We have demonstrated the existence of endogenous counterparts to sulfonylureas which we have called 'endosulfines.' In this review, we describe the discovery, isolation, cloning, and biological features of the high-molecular-mass form, alpha-endosulfine, and discuss its possible role in the physiology of the beta cell as well as in pathology.",
author = "D Bataille and L H{\'e}ron and A Virsolvy and K Peyrollier and A LeCam and L Gros and P Blache",
note = "Keywords: Adenosine Triphosphate; Amino Acid Sequence; Animals; Cloning, Molecular; Drosophila Proteins; Glucose; Humans; Insulin; Models, Biological; Molecular Sequence Data; Peptides; Potassium Channels; Sequence Homology, Amino Acid",
year = "1999",
language = "English",
volume = "56",
pages = "78--84",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Springer Basel AG",
number = "1-2",

}

RIS

TY - JOUR

T1 - alpha-Endosulfine, a new entity in the control of insulin secretion.

AU - Bataille, D

AU - Héron, L

AU - Virsolvy, A

AU - Peyrollier, K

AU - LeCam, A

AU - Gros, L

AU - Blache, P

N1 - Keywords: Adenosine Triphosphate; Amino Acid Sequence; Animals; Cloning, Molecular; Drosophila Proteins; Glucose; Humans; Insulin; Models, Biological; Molecular Sequence Data; Peptides; Potassium Channels; Sequence Homology, Amino Acid

PY - 1999

Y1 - 1999

N2 - ATP-dependent potassium (K ATP) channels occupy a key position in the control of insulin release from the pancreatic beta cell since they couple cell polarity to metabolism. These channels close when more ATP is produced via glucose metabolism. They are also controlled by sulfonylureas, a class of drugs used in type 2 diabetic patients for triggering insulin secretion from beta cells that have lost part of their sensitivity to glucose. We have demonstrated the existence of endogenous counterparts to sulfonylureas which we have called 'endosulfines.' In this review, we describe the discovery, isolation, cloning, and biological features of the high-molecular-mass form, alpha-endosulfine, and discuss its possible role in the physiology of the beta cell as well as in pathology.

AB - ATP-dependent potassium (K ATP) channels occupy a key position in the control of insulin release from the pancreatic beta cell since they couple cell polarity to metabolism. These channels close when more ATP is produced via glucose metabolism. They are also controlled by sulfonylureas, a class of drugs used in type 2 diabetic patients for triggering insulin secretion from beta cells that have lost part of their sensitivity to glucose. We have demonstrated the existence of endogenous counterparts to sulfonylureas which we have called 'endosulfines.' In this review, we describe the discovery, isolation, cloning, and biological features of the high-molecular-mass form, alpha-endosulfine, and discuss its possible role in the physiology of the beta cell as well as in pathology.

M3 - Journal article

C2 - 11213264

VL - 56

SP - 78

EP - 84

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 1-2

ER -

ID: 5241367