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Aluminium and nickel in human albumin solutions

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Five different brands of commercially available human albumin solutions for infusion were analysed for their aluminium and nickel contents by atomic absorption spectrometry. The aluminium concentrations ranged from 12 micrograms/l to 1109 micrograms/l and the nickel concentrations ranged from 17 micrograms/l to 77 micrograms/l. Examination of the aluminium and nickel contents of the constituents for the production of one brand showed too low levels to explain the final contamination of the product. By following the aluminium and nickel concentrations of the same brand during the production of a batch of albumin solution, filtration was shown to contribute to contamination, although the largest increase in aluminium as well as nickel concentrations appeared during the bulk concentrating process. To avoid health risks to certain patients, regulations should be established requiring aluminium and nickel contamination to be as low as possible.
OriginalsprogEngelsk
TidsskriftJournal of Trace Elements and Electrolytes in Health and Disease
Vol/bind3
Udgave nummer1
Sider (fra-til)39-42
Antal sider4
ISSN0931-2838
StatusUdgivet - 1989

ID: 44053170