Forskning ved Københavns Universitet - Københavns Universitet

Forside

Amyloid beta-peptide(25-35) changes [Ca2+] in hippocampal neurons

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Amyloid beta-peptide(25-35) changes [Ca2+] in hippocampal neurons. / Mogensen, Helle Smidt; Beatty, D M; Morris, S J; Jorgensen, O S.

I: NeuroReport, Bind 9, Nr. 7, 1998, s. 1553-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Mogensen, HS, Beatty, DM, Morris, SJ & Jorgensen, OS 1998, 'Amyloid beta-peptide(25-35) changes [Ca2+] in hippocampal neurons', NeuroReport, bind 9, nr. 7, s. 1553-8.

APA

Mogensen, H. S., Beatty, D. M., Morris, S. J., & Jorgensen, O. S. (1998). Amyloid beta-peptide(25-35) changes [Ca2+] in hippocampal neurons. NeuroReport, 9(7), 1553-8.

Vancouver

Mogensen HS, Beatty DM, Morris SJ, Jorgensen OS. Amyloid beta-peptide(25-35) changes [Ca2+] in hippocampal neurons. NeuroReport. 1998;9(7):1553-8.

Author

Mogensen, Helle Smidt ; Beatty, D M ; Morris, S J ; Jorgensen, O S. / Amyloid beta-peptide(25-35) changes [Ca2+] in hippocampal neurons. I: NeuroReport. 1998 ; Bind 9, Nr. 7. s. 1553-8.

Bibtex

@article{3c54b1d0e40011deba73000ea68e967b,
title = "Amyloid beta-peptide(25-35) changes [Ca2+] in hippocampal neurons",
abstract = "Insoluble aggregates of the amyloid beta-peptide (A beta) is a major constituent of senile plaques found in brains of Alzheimer disease (AD) patients. The detrimental effects of aggregated A beta is associated with an increased intracellular Ca2+ concentration ([Ca2+]i). We examined the effects of A beta(25-35) on [Ca2+]i and intracellular H+ concentration ([H+]i) in single hippocampal neurons by real time fluorescence imaging using the Ca(2+)- and H(+)-specific ratio dyes, indo-1 and SNARF-1. Incubation of these cultures with A beta(25-35) for 3-12 days in vitro increased [Ca2+]i and [H+]i in large, NMDA-responsive neurons.",
author = "Mogensen, {Helle Smidt} and Beatty, {D M} and Morris, {S J} and Jorgensen, {O S}",
note = "Keywords: Amyloid beta-Protein; Animals; Animals, Newborn; Astrocytes; Benzopyrans; Calcium; Cell Survival; Cells, Cultured; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Hippocampus; Hydrogen-Ion Concentration; Indoles; Kinetics; Microscopy, Fluorescence; Naphthols; Neurons; Peptide Fragments; Rats; Rhodamines; Time Factors",
year = "1998",
language = "English",
volume = "9",
pages = "1553--8",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams & Wilkins",
number = "7",

}

RIS

TY - JOUR

T1 - Amyloid beta-peptide(25-35) changes [Ca2+] in hippocampal neurons

AU - Mogensen, Helle Smidt

AU - Beatty, D M

AU - Morris, S J

AU - Jorgensen, O S

N1 - Keywords: Amyloid beta-Protein; Animals; Animals, Newborn; Astrocytes; Benzopyrans; Calcium; Cell Survival; Cells, Cultured; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Hippocampus; Hydrogen-Ion Concentration; Indoles; Kinetics; Microscopy, Fluorescence; Naphthols; Neurons; Peptide Fragments; Rats; Rhodamines; Time Factors

PY - 1998

Y1 - 1998

N2 - Insoluble aggregates of the amyloid beta-peptide (A beta) is a major constituent of senile plaques found in brains of Alzheimer disease (AD) patients. The detrimental effects of aggregated A beta is associated with an increased intracellular Ca2+ concentration ([Ca2+]i). We examined the effects of A beta(25-35) on [Ca2+]i and intracellular H+ concentration ([H+]i) in single hippocampal neurons by real time fluorescence imaging using the Ca(2+)- and H(+)-specific ratio dyes, indo-1 and SNARF-1. Incubation of these cultures with A beta(25-35) for 3-12 days in vitro increased [Ca2+]i and [H+]i in large, NMDA-responsive neurons.

AB - Insoluble aggregates of the amyloid beta-peptide (A beta) is a major constituent of senile plaques found in brains of Alzheimer disease (AD) patients. The detrimental effects of aggregated A beta is associated with an increased intracellular Ca2+ concentration ([Ca2+]i). We examined the effects of A beta(25-35) on [Ca2+]i and intracellular H+ concentration ([H+]i) in single hippocampal neurons by real time fluorescence imaging using the Ca(2+)- and H(+)-specific ratio dyes, indo-1 and SNARF-1. Incubation of these cultures with A beta(25-35) for 3-12 days in vitro increased [Ca2+]i and [H+]i in large, NMDA-responsive neurons.

M3 - Journal article

C2 - 9631466

VL - 9

SP - 1553

EP - 1558

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 7

ER -

ID: 16159446