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An exploratory model for G x E interaction on hippocampal volume in schizophrenia; obstetric complications and hypoxia-related genes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Unn Kristin Haukvik
  • Peter Saetre
  • Thomas McNeil
  • Petr S Bjerkan
  • Ole A Andreassen
  • Werge, Thomas
  • Erik G Jönsson
  • Ingrid Agartz
Smaller hippocampal volume has repeatedly been reported in schizophrenia patients. Obstetric complications (OCs) and single nucleotide polymorphism (SNP) variation in schizophrenia susceptibility genes have independently been related to hippocampal volume. We investigated putative independent and interaction effects of severe hypoxia-related OCs and variation in four hypoxia-regulated schizophrenia susceptibility genes (BDNF, DTNBP1, GRM3 and NRG1) on hippocampal volume in schizophrenia patients and healthy controls.
OriginalsprogEngelsk
TidsskriftProgress in Neuro-Psychopharmacology & Biological Psychiatry
Vol/bind34
Udgave nummer7
Sider (fra-til)1259-65
Antal sider7
ISSN0278-5846
DOI
StatusUdgivet - 1 okt. 2010

ID: 34193844