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An mRNA is capped by a 2', 5' lariat catalyzed by a group I-like ribozyme

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Standard

An mRNA is capped by a 2', 5' lariat catalyzed by a group I-like ribozyme. / Nielsen, Henrik; Westhof, Eric; Johansen, Steinar.

I: Science, Bind 309, Nr. 5740, 2005, s. 1584-7.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Nielsen, H, Westhof, E & Johansen, S 2005, 'An mRNA is capped by a 2', 5' lariat catalyzed by a group I-like ribozyme', Science, bind 309, nr. 5740, s. 1584-7. https://doi.org/10.1126/science.1113645

APA

Nielsen, H., Westhof, E., & Johansen, S. (2005). An mRNA is capped by a 2', 5' lariat catalyzed by a group I-like ribozyme. Science, 309(5740), 1584-7. https://doi.org/10.1126/science.1113645

Vancouver

Nielsen H, Westhof E, Johansen S. An mRNA is capped by a 2', 5' lariat catalyzed by a group I-like ribozyme. Science. 2005;309(5740):1584-7. https://doi.org/10.1126/science.1113645

Author

Nielsen, Henrik ; Westhof, Eric ; Johansen, Steinar. / An mRNA is capped by a 2', 5' lariat catalyzed by a group I-like ribozyme. I: Science. 2005 ; Bind 309, Nr. 5740. s. 1584-7.

Bibtex

@article{7922b0c0a75c11debc73000ea68e967b,
title = "An mRNA is capped by a 2', 5' lariat catalyzed by a group I-like ribozyme",
abstract = "Twin-ribozyme introns are formed by two ribozymes belonging to the group I family and occur in some ribosomal RNA transcripts. The group I-like ribozyme, GIR1, liberates the 5' end of a homing endonuclease messenger RNA in the slime mold Didymium iridis. We demonstrate that this cleavage occurs by a transesterification reaction with the joining of the first and the third nucleotide of the messenger by a 2',5'-phosphodiester linkage. Thus, a group I-like ribozyme catalyzes an RNA branching reaction similar to the first step of splicing in group II introns and spliceosomal introns. The resulting short lariat, by forming a protective 5' cap, might have been useful in a primitive RNA world.",
author = "Henrik Nielsen and Eric Westhof and Steinar Johansen",
note = "Keywords: Base Sequence; Catalysis; Endonucleases; Esterification; Introns; Molecular Sequence Data; RNA Caps; RNA Splicing; RNA, Catalytic",
year = "2005",
doi = "10.1126/science.1113645",
language = "English",
volume = "309",
pages = "1584--7",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5740",

}

RIS

TY - JOUR

T1 - An mRNA is capped by a 2', 5' lariat catalyzed by a group I-like ribozyme

AU - Nielsen, Henrik

AU - Westhof, Eric

AU - Johansen, Steinar

N1 - Keywords: Base Sequence; Catalysis; Endonucleases; Esterification; Introns; Molecular Sequence Data; RNA Caps; RNA Splicing; RNA, Catalytic

PY - 2005

Y1 - 2005

N2 - Twin-ribozyme introns are formed by two ribozymes belonging to the group I family and occur in some ribosomal RNA transcripts. The group I-like ribozyme, GIR1, liberates the 5' end of a homing endonuclease messenger RNA in the slime mold Didymium iridis. We demonstrate that this cleavage occurs by a transesterification reaction with the joining of the first and the third nucleotide of the messenger by a 2',5'-phosphodiester linkage. Thus, a group I-like ribozyme catalyzes an RNA branching reaction similar to the first step of splicing in group II introns and spliceosomal introns. The resulting short lariat, by forming a protective 5' cap, might have been useful in a primitive RNA world.

AB - Twin-ribozyme introns are formed by two ribozymes belonging to the group I family and occur in some ribosomal RNA transcripts. The group I-like ribozyme, GIR1, liberates the 5' end of a homing endonuclease messenger RNA in the slime mold Didymium iridis. We demonstrate that this cleavage occurs by a transesterification reaction with the joining of the first and the third nucleotide of the messenger by a 2',5'-phosphodiester linkage. Thus, a group I-like ribozyme catalyzes an RNA branching reaction similar to the first step of splicing in group II introns and spliceosomal introns. The resulting short lariat, by forming a protective 5' cap, might have been useful in a primitive RNA world.

U2 - 10.1126/science.1113645

DO - 10.1126/science.1113645

M3 - Journal article

C2 - 16141078

VL - 309

SP - 1584

EP - 1587

JO - Science

JF - Science

SN - 0036-8075

IS - 5740

ER -

ID: 14612067