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Angiogenesis in vestibular schwannomas: expression of extracellular matrix factors MMP-2, MMP-9, and TIMP-1

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Martin Nue Møller
  • Kim Werther
  • Amarnadh Nalla
  • Sven-Eric Stangerup
  • Jens Thomsen
  • Thorkild C Bøg-Hansen
  • Hans Jørgen Nielsen
  • Cayé-Thomasen, Per
Vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) are potent mediators of tumor angiogenesis. It has been demonstrated that vestibular schwannoma VEGF expression correlates with tumor growth pattern, whereas knowledge on the expression of MMPs is lacking. This study targets the angiogenic process by investigation of tumor expression of MMP-2, MMP-9, and tissue inhibitors of metalloproteinase (TIMP)-1. A possible correlation with gender, patient age, symptom duration, tumor size, and the absolute and relative growth rate is explored.
OriginalsprogEngelsk
TidsskriftLaryngoscope
Vol/bind120
Udgave nummer4
Sider (fra-til)657-62
Antal sider6
ISSN0023-852X
DOI
StatusUdgivet - 2010

ID: 41800723